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Title: | Eosinophilia and acquisition of resistance to nematospiroides dubius in mice sensitized with adult worms. |
Authors: | Hurley, James C. Vadas, M. A. |
Issue Date: | 1983 |
Publisher: | University of Adelaide |
Place of publication: | Adelaide |
Publication Title: | The Australian Journal of Experimental Biology and Medical Science |
Volume: | 61 |
Issue: | 1 |
Start Page: | 1 |
End Page: | 9 |
Abstract: | BALB/c mice develop resistance to challenge with N. dubius third stage infective larvae (L3) 2-3 weeks after the administration of N. dubius worms. In contrast, CBA/H mice fail to develop resistance. Experiments were performed to test the hypothesis that the reason for the different behaviour of these mice was a difference in their eosinophil response. BALB/c mice and BALB/c leads to (BALB/c x CBA/H)F1 bone marrow chimaeras but not CBA/H mice or CBA/H leads to (BALB/c x CBA/H)F1 chimaeras mounted strong eosinophilia after N. dubius sensitization and the eosinophil response was associated with resistance to L3 infection in these mice. Induction of a mild eosinophilia in CBA/H mice by non-parasite antigen keyhole limpet haemocyanin (KLH) in complete Freund's adjuvant (CFA) following cyclophosphamide (CY) treatment was associated with the acquisition of a degree of resistance to L3 infection. In BALB/c mice, increase in eosinophilia induced by CY and KLH-CFA was not associated with a further reduction in worm numbers. These experiments support the hypothesis that eosinophilia is an important component of host protective immunity in vivo, and suggest a new basis for the heterogeneity of the outcome of some parasite infestations. |
URI: | http://hdl.handle.net/11054/49 |
ISSN: | 0004-945X |
Internal ID Number: | 00036 |
Health Subject: | ANIMALS ANTIGENS - ADMINISTRATION AND DOSAGE CYCLOPHOSPHAMIDE - ADMINISTRATION AND DOSAGE DOSE RESPONSE RELATIONSHIP - IMMUNOLOGIC EOSINOPHILIA - ETIOLOGY EOSINOPHILIA - IMMUNOLOGY FEMALE FREUND'S ADJUVANT - ADMINISTRATION AND DOSAGE HEMOCYANIN INNATE IMMUNITY IMMUNISATION MICE TIME FACTORS RADIATION CHIMERA NEMATODE INFECTIONS ANTIGENS KEYHOLE LIMPET HEMOCYANIN CYCLOPHOSPHAMIDE FREUND'S ADJUVANT |
Type: | Journal Article Article |
Appears in Collections: | Research Output |
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