Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/49
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dc.contributor.authorHurley, James C.en
dc.contributor.authorVadas, M. A.en
dc.date.accessioned2012-10-23T03:30:19Zen
dc.date.available2012-10-23T03:30:19Zen
dc.date.issued1983en
dc.identifier.govdoc00036en
dc.identifier.issn0004-945Xen
dc.identifier.urihttp://hdl.handle.net/11054/49en
dc.description.abstractBALB/c mice develop resistance to challenge with N. dubius third stage infective larvae (L3) 2-3 weeks after the administration of N. dubius worms. In contrast, CBA/H mice fail to develop resistance. Experiments were performed to test the hypothesis that the reason for the different behaviour of these mice was a difference in their eosinophil response. BALB/c mice and BALB/c leads to (BALB/c x CBA/H)F1 bone marrow chimaeras but not CBA/H mice or CBA/H leads to (BALB/c x CBA/H)F1 chimaeras mounted strong eosinophilia after N. dubius sensitization and the eosinophil response was associated with resistance to L3 infection in these mice. Induction of a mild eosinophilia in CBA/H mice by non-parasite antigen keyhole limpet haemocyanin (KLH) in complete Freund's adjuvant (CFA) following cyclophosphamide (CY) treatment was associated with the acquisition of a degree of resistance to L3 infection. In BALB/c mice, increase in eosinophilia induced by CY and KLH-CFA was not associated with a further reduction in worm numbers. These experiments support the hypothesis that eosinophilia is an important component of host protective immunity in vivo, and suggest a new basis for the heterogeneity of the outcome of some parasite infestations.en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2012-10-23T03:30:19Z (GMT) No. of bitstreams: 0en
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2012-10-23T03:30:04ZNo. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2012-10-23T03:30:19Z (GMT). No. of bitstreams: 0 Previous issue date: 1983en
dc.publisherUniversity of Adelaideen
dc.titleEosinophilia and acquisition of resistance to nematospiroides dubius in mice sensitized with adult worms.en
dc.typeJournal Articleen
dc.type.specifiedArticleen
dc.bibliographicCitation.titleThe Australian Journal of Experimental Biology and Medical Scienceen
dc.bibliographicCitation.volume61en
dc.bibliographicCitation.issue1en
dc.bibliographicCitation.stpage1en
dc.bibliographicCitation.endpage9en
dc.publisher.placeAdelaideen
dc.subject.healththesaurusANIMALSen
dc.subject.healththesaurusANTIGENS - ADMINISTRATION AND DOSAGEen
dc.subject.healththesaurusCYCLOPHOSPHAMIDE - ADMINISTRATION AND DOSAGEen
dc.subject.healththesaurusDOSE RESPONSE RELATIONSHIP - IMMUNOLOGICen
dc.subject.healththesaurusEOSINOPHILIA - ETIOLOGYen
dc.subject.healththesaurusEOSINOPHILIA - IMMUNOLOGYen
dc.subject.healththesaurusFEMALEen
dc.subject.healththesaurusFREUND'S ADJUVANT - ADMINISTRATION AND DOSAGEen
dc.subject.healththesaurusHEMOCYANINen
dc.subject.healththesaurusINNATE IMMUNITYen
dc.subject.healththesaurusIMMUNISATIONen
dc.subject.healththesaurusMICEen
dc.subject.healththesaurusTIME FACTORSen
dc.subject.healththesaurusRADIATION CHIMERAen
dc.subject.healththesaurusNEMATODE INFECTIONSen
dc.subject.healththesaurusANTIGENSen
dc.subject.healththesaurusKEYHOLE LIMPET HEMOCYANINen
dc.subject.healththesaurusCYCLOPHOSPHAMIDEen
dc.subject.healththesaurusFREUND'S ADJUVANTen
dc.date.issuedbrowse1983-01-01en
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