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Title: The journey of drug-eluting stents: a multi-centre Australian Registry Review.
Author: Yeoh, J.
Andrianopoulos, Nick
Yudi, M.
Horrigan, M.
Horrigan, S.
Ajani, A.
O'Brien, J.
Brennan, A.
Proimos, G.
Picardo, S.
Freeman, M.
Oqueli, Ernesto
Sebastian, M.
Reid, C.
Farouque, O.
Clark, D.
Issue Date: 2018
Conference Name: 66th Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 12th Annual Australia and New Zealand Endovascular Therapies Meeting.
Conference Date: August 2-5th
Conference Place: Brisbane, Queensland
Abstract: Background: Drug-eluting stents (DES) were introduced in Australia in 2002. Initial use was restricted to high-restenosis-risk patients, due to cost and late stent thrombosis concerns, particularly the first-generation type. This study reviewed the Melbourne Interventional Group (MIG) experience of percutaneous coronary intervention (PCI) with DES to examine trends, outcomes, and compare the long-term morality of first-generation to later-generation stent types. Method: Consecutive patients who underwent DES PCI from the MIG registry between 2005 and 2017 were analysed with yearly comparison. National Death Index (NDI) linkage was used to determine 5-year mortality and for Cox proportional hazards modelling. Results: A total of 15,329 procedures were captured. Major trends are shown below. Twelve-month target vessel revascularisation (available until 2011) was 3.56% compared to 5.75% in 2005 (p = 0.09). Five-year mortality (available until 2012) was 12.1% compared to 12.8% in 2005 (p = 0.25). There was no difference in long-term mortality between first-generation and later-generation DES (22.2% vs 23.6%, p = 0.86). First-generation DES was not an independent predictor of long-term mortality (HR 1.11, 95% CI 0.91–1.36, p = 0.30). Conclusion: Uptake of DES was slow, but they are now almost universally recommended. There was no evidence of higher long-term mortality with first-generation DES in this Australian multi-centre registry.
Internal ID Number: 01252
Type: Conference
Appears in Collections:Research Output

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