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http://hdl.handle.net/11054/1210
Title: | World-wide variation in incidence of staphylococcus aureus associated ventilator-associated pneumonia: a meta-regression. |
Author: | Hurley, James C. |
Issue Date: | 2018 |
Publication Title: | Microorganisms |
Volume: | 6 |
Issue: | 1 |
Start Page: | 18 |
Abstract: | Staphylococcus aureus (S. aureus) is a common Ventilator-Associated Pneumonia (VAP) isolate. The objective here is to define the extent and possible reasons for geographic variation in the incidences of S. aureus-associated VAP, MRSA-VAP and overall VAP. A meta-regression model of S. aureus-associated VAP incidence per 1000 Mechanical Ventilation Days (MVD) was undertaken using random effects methods among publications obtained from a search of the English language literature. This model incorporated group level factors such as admission to a trauma ICU, year of publication and use of bronchoscopic sampling towards VAP diagnosis. The search identified 133 publications from seven worldwide regions published over three decades. The summary S. aureus-associated VAP incidence was 4.5 (3.9-5.3) per 1000 MVD. The highest S. aureus-associated VAP incidence is amongst reports from the Mediterranean (mean; 95% confidence interval; 6.1; 4.1-8.5) versus that from Asian ICUs (2.1; 1.5-3.0). The incidence of S. aureus-associated VAP varies by up to three-fold (for the lowest versus highest incidence) among seven geographic regions worldwide, whereas the incidence of VAP varies by less than two-fold. Admission to a trauma unit is the most important group level correlate for S. aureus-associated VAP. |
URI: | http://hdl.handle.net/11054/1210 |
ISSN: | 2076-2607 |
DOI: | https://doi.org/10.3390/microorganisms6010018 |
Internal ID Number: | 01137 |
Health Subject: | VENTILATOR-ASSOCIATED PNEUMONIA STAPHLOCOCCUS AUREUS TRAUMA CENTRES TRAUMA INCIDENCE RESPIRATION, ARTIFICIAL INTENSIVE CARE UNITS STAPHYLOCOCCAL INFECTIONS |
Type: | Journal Article Article |
Appears in Collections: | Research Output |
Files in This Item:
File | Description | Size | Format | |
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microorganisms-06-00018.pdf | 3.29 MB | Adobe PDF | View/Open |
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