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dc.contributorHurley, James C.en_US
dc.date.accessioned2018-09-06T00:56:07Z-
dc.date.available2018-09-06T00:56:07Z-
dc.date.issued2018-
dc.identifier.govdoc01137en_US
dc.identifier.issn2076-2607en_US
dc.identifier.urihttp://hdl.handle.net/11054/1210-
dc.description.abstractStaphylococcus aureus (S. aureus) is a common Ventilator-Associated Pneumonia (VAP) isolate. The objective here is to define the extent and possible reasons for geographic variation in the incidences of S. aureus-associated VAP, MRSA-VAP and overall VAP. A meta-regression model of S. aureus-associated VAP incidence per 1000 Mechanical Ventilation Days (MVD) was undertaken using random effects methods among publications obtained from a search of the English language literature. This model incorporated group level factors such as admission to a trauma ICU, year of publication and use of bronchoscopic sampling towards VAP diagnosis. The search identified 133 publications from seven worldwide regions published over three decades. The summary S. aureus-associated VAP incidence was 4.5 (3.9-5.3) per 1000 MVD. The highest S. aureus-associated VAP incidence is amongst reports from the Mediterranean (mean; 95% confidence interval; 6.1; 4.1-8.5) versus that from Asian ICUs (2.1; 1.5-3.0). The incidence of S. aureus-associated VAP varies by up to three-fold (for the lowest versus highest incidence) among seven geographic regions worldwide, whereas the incidence of VAP varies by less than two-fold. Admission to a trauma unit is the most important group level correlate for S. aureus-associated VAP.en_US
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dc.description.provenanceMade available in DSpace on 2018-09-06T00:56:07Z (GMT). No. of bitstreams: 1 microorganisms-06-00018.pdf: 3371624 bytes, checksum: c0ba9418db66e19079511672ba05f602 (MD5) Previous issue date: 2018en
dc.titleWorld-wide variation in incidence of staphylococcus aureus associated ventilator-associated pneumonia: a meta-regression.en_US
dc.typeJournal Articleen_US
dc.type.specifiedArticleen_US
dc.bibliographicCitation.titleMicroorganismsen_US
dc.bibliographicCitation.volume6en_US
dc.bibliographicCitation.issue1en_US
dc.bibliographicCitation.stpage18en_US
dc.subject.healththesaurusVENTILATOR-ASSOCIATED PNEUMONIAen_US
dc.subject.healththesaurusSTAPHLOCOCCUS AUREUSen_US
dc.subject.healththesaurusTRAUMA CENTRESen_US
dc.subject.healththesaurusTRAUMAen_US
dc.subject.healththesaurusINCIDENCEen_US
dc.subject.healththesaurusRESPIRATION, ARTIFICIALen_US
dc.subject.healththesaurusINTENSIVE CARE UNITSen_US
dc.subject.healththesaurusSTAPHYLOCOCCAL INFECTIONSen_US
dc.identifier.doihttps://doi.org/10.3390/microorganisms6010018en_US
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