Massive fibroelastosis of gallbladder, a rare entity: report of a case.

Abstract

Fibroelastosis is a rare entity in the gallbladder, not well described in the literature, for which the aetiology remains uncertain. We report here a case of massive fibroelastosis of gallbladder in association with smouldering cholecystitis and cholelithiasis. The gallbladder showed a 13 mm white nodule at the fundus. On histology the nodule was composed of degenerate elastin and collagen, demonstrated with elastic-Van Gieson (EVG) and trichrome stains. Literature search reveals only three cases of gallbladder fibroelastosis. 1-3 The origin of elastosis in such an unusual site is not well understood. Bile leakage into interstitium or local tissue response to cytokines liberated by histiocytes may play a role.