Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/50
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dc.contributor.authorHurley, James C.en
dc.contributor.authorDay, K. P.en
dc.contributor.authorMitchell, G. F.en
dc.date.accessioned2012-10-23T03:47:48Zen
dc.date.available2012-10-23T03:47:48Zen
dc.date.issued1980en
dc.identifier.govdoc00037en
dc.identifier.issn0004-945Xen
dc.identifier.urihttp://hdl.handle.net/11054/50en
dc.description.abstractAfter oral administration of infective third stage larvae (L3) of Nematospiroides dubius to young mice, intestinal worms persist for many weeks. However, in mice injected parenterally with N. dubius adult worms, the intraluminal intestinal infection arising after L3 administration can be terminated within 3 to 4 weeks. This accelerated rejection is seen in sensitized BALB/c mice (and (CBA/H X BALB/c)F1 mice) and in particular females, but has not been demonstrated in sensitized CBA/H mice. In female BALB/c mice, small numbers of living worms are more effective at sensitization than dead worms, intraperitoneal and subcutaneous implantations are both effective, and products from adult worms incubated in vitro (i.e. "excretory/secretory" (ES) products) will sensitize but only with very high doses in adjuvant. Using appropriate isolated antigen preparations, comparative immunoparasitological analyses in different mice should provide clues on the nature of host-protective immunities against intestinal nematode infections which are potentially chronic. From the present studies, two groups which differ most dramatically in the consequences of adult worm sensitization are young male CBA/H versus older female BALB/c mice.en
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2012-10-23T03:47:29Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2012-10-23T03:47:48Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2012-10-23T03:47:48Z (GMT). No. of bitstreams: 0 Previous issue date: 1980en
dc.publisherUniversity of Adelaideen
dc.titleAccelerated rejection of nematospiroides dubius intestinal worms in mice sensitized with adult worms.en
dc.typeJournal Articleen
dc.type.specifiedArticleen
dc.bibliographicCitation.titleThe Australian Journal of Experimental Biology and Medical Scienceen
dc.bibliographicCitation.titleImmunology and Cell Biologyen
dc.bibliographicCitation.volume58en
dc.bibliographicCitation.issue3en
dc.bibliographicCitation.stpage231en
dc.bibliographicCitation.endpage240en
dc.publisher.placeAdelaideen
dc.subject.healththesaurusANIMALSen
dc.subject.healththesaurusANTIGENS - IMMUNOLOGYen
dc.subject.healththesaurusANTIGENS - ISOLATION AND PURIFICATIONen
dc.subject.healththesaurusFEMALEen
dc.subject.healththesaurusIMMUNITYen
dc.subject.healththesaurusIMMUNISATIONen
dc.subject.healththesaurusINTESTINAL DISEASESen
dc.subject.healththesaurusLARVAen
dc.subject.healththesaurusMALEen
dc.subject.healththesaurusMICEen
dc.subject.healththesaurusANTIGENSen
dc.subject.healththesaurusTIME FACTORSen
dc.subject.healththesaurusNEMATODE INFECTIONS - IMMUNOLOGYen
dc.subject.healththesaurusINTESTINES - PARASITOLOGYen
dc.date.issuedbrowse1980-01-01en
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