Please use this identifier to cite or link to this item:
|Title:||The effects of food on the oral bioavailability of doxazosin in hypertensive subjects.|
|Authors:||Conway, E. L.|
McNeil, J. J.
Hurley, James C.
Jackman, G. P.
Howes, L. G.
Louis, W. J.
|Publication Title:||Clinical Drug Investigation|
|Abstract:||The bioavailability of and pharmacodynamic responses to doxazosin, administered with and without food, were examined in a crossover study in 12 hypertensive subjects. The administration of doxazosin with food delayed its absorption by approximately 1 hour, reduced the maximum (peak) plasma drug concentration after single dose administration (Cmax) by 18%, and reduced the area under the plasma concentration-time curve (AUC) by 12%; however, these effects were not statistically significant. The acute fall in blood pressure following doxazosin administration was not significantly affected by food; however, there was a trend towards a lower incidence of complaints in this group. The effect of coadministration of food on the pharmacokinetic and pharmacodynamic responses to doxazosin are unlikely to be of clinical significance.|
|Internal ID Number:||00028|
|Appears in Collections:||Research Output|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.