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Title: The effects of food on the oral bioavailability of doxazosin in hypertensive subjects.
Authors: Conway, E. L.
McNeil, J. J.
Hurley, James C.
Jackman, G. P.
Krum, Henry
Howes, L. G.
Louis, W. J.
Issue Date: 1993
Publisher: Adis
Publication Title: Clinical Drug Investigation
Volume: 6
Issue: 2
Start Page: 91
End Page: 95
Abstract: The bioavailability of and pharmacodynamic responses to doxazosin, administered with and without food, were examined in a crossover study in 12 hypertensive subjects. The administration of doxazosin with food delayed its absorption by approximately 1 hour, reduced the maximum (peak) plasma drug concentration after single dose administration (Cmax) by 18%, and reduced the area under the plasma concentration-time curve (AUC) by 12%; however, these effects were not statistically significant. The acute fall in blood pressure following doxazosin administration was not significantly affected by food; however, there was a trend towards a lower incidence of complaints in this group. The effect of coadministration of food on the pharmacokinetic and pharmacodynamic responses to doxazosin are unlikely to be of clinical significance.
ISSN: 0114-2402
Internal ID Number: 00028
Health Subject: DOXAZOSIN
Type: Journal Article
Appears in Collections:Research Output

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