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http://hdl.handle.net/11054/41
Title: | The effects of food on the oral bioavailability of doxazosin in hypertensive subjects. |
Authors: | Conway, E. L. McNeil, J. J. Hurley, James C. Jackman, G. P. Krum, Henry Howes, L. G. Louis, W. J. |
Issue Date: | 1993 |
Publisher: | Adis |
Publication Title: | Clinical Drug Investigation |
Volume: | 6 |
Issue: | 2 |
Start Page: | 91 |
End Page: | 95 |
Abstract: | The bioavailability of and pharmacodynamic responses to doxazosin, administered with and without food, were examined in a crossover study in 12 hypertensive subjects. The administration of doxazosin with food delayed its absorption by approximately 1 hour, reduced the maximum (peak) plasma drug concentration after single dose administration (Cmax) by 18%, and reduced the area under the plasma concentration-time curve (AUC) by 12%; however, these effects were not statistically significant. The acute fall in blood pressure following doxazosin administration was not significantly affected by food; however, there was a trend towards a lower incidence of complaints in this group. The effect of coadministration of food on the pharmacokinetic and pharmacodynamic responses to doxazosin are unlikely to be of clinical significance. |
URI: | http://hdl.handle.net/11054/41 |
ISSN: | 0114-2402 |
Internal ID Number: | 00028 |
Health Subject: | DOXAZOSIN FOOD HUMANS PHARMACODYNAMIC RESPONSE HYPERTENSIVE |
Type: | Journal Article Article |
Appears in Collections: | Research Output |
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