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http://hdl.handle.net/11054/32
Title: | Paracetamol overdose and hepatotoxicity at a regional Australian hospital: a 4-year experience. |
Authors: | Ayonrinde, O. T. Phelps, Grant J. Hurley, James C. Ayonrinde, O. A. |
Issue Date: | 2005 |
Publisher: | Blackwell Science Asia |
Place of publication: | Carlton, Victoria |
Publication Title: | Australian and New Zealand Journal of Medicine |
Volume: | 35 |
Issue: | 11 |
Start Page: | 655 |
End Page: | 660 |
Abstract: | BACKGROUND: Paracetamol is a component of a number of drugs taken in overdose (OD). The influence of alcohol use (acute or chronic) on the presentation and clinical course of paracetamol OD is contentious. This study explores the relationship between paracetamol OD, alcohol consumption and clinical outcomes at a regional Australian hospital. AIMS: To determine the frequency, circumstances and outcomes of paracetamol OD presentations to a regional Australian general hospital over a 4-year period. METHODS: Medical records of patients admitted to the Ballarat Health Services (BHS) as a result of paracetamol OD between January 2000 and December 2003 were reviewed. Patient demographics, amount of paracetamol ingested, other drug coingestions, alcohol history, previous medication OD, clinical course and outcomes were recorded. RESULTS: Annual admissions resulting from paracetamol OD almost doubled during the 4 years studied. The risk of a repeat paracetamol OD was highest within 4 weeks of the initial OD. Alcohol, benzodiazepines and antidepressants were commonly coingested. The strongest predictor of severe hepatotoxicity was delayed or no N-acetyl cysteine treatment in patients consuming greater than 10 g of paracetamol or with toxic serum paracetamol levels. A history of alcohol consumption did not appear to worsen outcomes. |
URI: | http://hdl.handle.net/11054/32 |
ISSN: | 1444-0903 |
Internal ID Number: | 00019 |
Health Subject: | ACETAMINOPHEN POISONING ADOLESCENT ADULT AGE DISTRIBUTION AGED AGED 80 AND OVER ALCOHOL DRINKING - EPIDEMIOLOGY AUSTRALIA - EPIDEMIOLOGY CHILD COMORBIDITY DRUG INDUCED LIVER INJURY - EPIDEMIOLOGY DRUG INDUCED LIVER INJURY - ETIOLOGY FEMALE HOSPITALIZATION STATISTICS AND NUMERICAL DATA HUMANS INFANT MALE OVERDOSE PREVALENCE MIDDLE AGED RETROSPECTIVE STUDIES RISK ASSESSMENT - METHODS RISK FACTORS SEX DISTRIBUTION ACETAMINOPHEN |
Type: | Journal Article Article |
Appears in Collections: | Research Output |
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