Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/2760
Full metadata record
DC FieldValueLanguage
dc.contributorShet, P.en_US
dc.contributorMustafa, A.en_US
dc.contributorVarshney, K.en_US
dc.contributorRao, L.en_US
dc.contributorSawdagar, S.en_US
dc.contributorMcLennan, F.en_US
dc.contributorAnsari, S.en_US
dc.contributorShet, D.en_US
dc.contributorSivathamboo, Niveshanen_US
dc.contributorCampbell, Sianen_US
dc.date.accessioned2024-11-27T04:28:26Z-
dc.date.available2024-11-27T04:28:26Z-
dc.date.issued2024-
dc.identifier.govdoc02751en_US
dc.identifier.urihttp://hdl.handle.net/11054/2760-
dc.description.abstractBackground: Fournier gangrene (FG) is a form of necrotizing fasciitis involving the perineal, peri-anal, and genital structures, and has exceptionally high mortality rates. To help in early detection of high-risk patients, we aimed to systematically review factors associated with mortality from FG. Patients and Methods: Searches were conducted in PubMed, Embase and Scopus. In our review, a minimum of five patients were required and this was to exclude studies with exceedingly small sample sizes, such as case reports and small case series, with minimal relevance in comparison to larger scale studies. Patient characteristics, causative microbes, anatomic areas of infection, presence of comorbidities, severity scores, causes of FG, and complications were extracted and compared to identify factors related to mortality. Results: A total of 57 studies were included in the review. Across 3,646 study participants, the mortality rate of FG was 20.41%. The mean age of non-survivors was 61.27 years. There were more total male deaths, however, the mortality rate was higher in females. Diabetes mellitus was the most common comorbidity in those who died, but the highest mortality rate was seen in HIV patients (54.17%). Mortality rates did not differ widely among antibiotic agents. Regarding causative organisms, fungal infections had the highest rates of mortality (68.18%) and the most common microbe leading to death was Escherichia coli. Conclusions: Female gender, comorbidities, anatomic distribution, development of sepsis, and fungal infection all increased risk for mortality. Early identification of risk factors, and provision of appropriate treatment are crucial in reducing mortality rates of high-risk patients with FG.en_US
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2024-07-11T03:21:45Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2024-11-27T04:28:26Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2024-11-27T04:28:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2024en
dc.titleRisk factors for mortality among patients with Fournier gangrene: A systematic review.en_US
dc.typeJournal Articleen_US
dc.type.specifiedArticleen_US
dc.bibliographicCitation.titleSurgical Infectionsen_US
dc.bibliographicCitation.volume25en_US
dc.bibliographicCitation.issue4en_US
dc.bibliographicCitation.stpage261en_US
dc.bibliographicCitation.endpage271en_US
dc.subject.healththesaurusFOURNIER GANGRENEen_US
dc.subject.healththesaurusMICROBESen_US
dc.subject.healththesaurusMORTALITYen_US
dc.subject.healththesaurusNECROTIZING FASCIITISen_US
dc.subject.healththesaurusRISK FACTORSen_US
dc.identifier.doihttps://doi.org/10.1089/sur.2023.372en_US
Appears in Collections:Research Output

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.