Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGilbert, Georgeen
dc.contributor.authorYoung, Valen
dc.contributor.authorGoodall, Ianen
dc.contributor.authorJerums, Georgeen
dc.description.abstractOBJECTIVE: To determine the extent of interlaboratory variation and accuracy in the measurement of glycated hemoglobin (GHb). RESEARCH DESIGN AND METHODS: All laboratories that measure glycated hemoglobin in the State of Victoria, Australia, were invited to participate, and positive responses were received from 27 to 30 laboratories. An aliquot of blood drawn from three patients with diabetes and varied glycemia and from one nondiabetic subject was sent to each participating laboratory. Distribution of results was analyzed according to the reported results and their variance from an assigned reference value and were expressed as differing from this latter value as percentage bias and in absolute terms. A bias > or = 10% or an absolute difference of > or = 1% HbA1c from the reference value was considered significant. RESULTS: Reported results for the same blood sample ranged from 4.1 to 5.8%, 5.1 to 8.2%, 6.7 to 9.3%, and 10.1 to 14.7% for the specimens from the nondiabetic subject and the diabetic patients with good, moderate, and poor glycemic control, respectively. The proportion of laboratories with results that differed by > or = 10% bias from the reference value were 39% (12 of 30), 29% (9 of 30), 16% (5 of 30), and 32% (10 of 30), and the proportion reporting results that differed by > or = 1% HbA1c in absolute terms from the reference values were 3% (1 of 30), 6% (2 of 30), 16% (5 of 30), and 23% (7 of 30) for the specimens from the nondiabetic subject and the diabetic patients with good, moderate, and poor glycemic control, respectively. CONCLUSIONS: A substantial degree of interlaboratory variation for GHb measurement exists in Victoria, Australia. This may lead to difficulties in interpretation when GHb is assayed by different laboratories in the same patient over time. Interlaboratory standardization may be achievable by calibration to a standard assigned by a reference laboratory and distributed to all laboratories measuring GHb. This study was undertaken with assistance from the Ballarat Base Hospital pathology laboratory.en
dc.description.provenanceSubmitted by Gemma Siemensma ( on 2013-05-22T05:18:21Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma ( on 2013-05-28T05:42:06Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2013-05-28T05:42:06Z (GMT). No. of bitstreams: 0 Previous issue date: 1996en
dc.publisherAmerican Diabetes Associationen
dc.titleInterlaboratory variation of GHb assays in Victoria, Australia.en
dc.typeJournal Articleen
dc.bibliographicCitation.titleDiabetes Careen
dc.publisher.placeIndianapolis, IN.en
dc.subject.healththesaurusGLYCATED HEMOGLOBINen
dc.subject.healththesaurusGLYCAEMIC CONTROLen
dc.subject.healththesaurusBLOOD GLUCOSEen
dc.subject.healththesaurusCASE STUDYen
Appears in Collections:Research Output

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.