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DC Field | Value | Language |
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dc.contributor | Hassan, Y. | en_US |
dc.contributor | Connell, W. | en_US |
dc.contributor | Rawal, Alisha | en_US |
dc.contributor | Wright, E. | en_US |
dc.date.accessioned | 2023-08-08T11:03:44Z | - |
dc.date.available | 2023-08-08T11:03:44Z | - |
dc.date.issued | 2023 | - |
dc.identifier.govdoc | 02260 | en_US |
dc.identifier.uri | http://hdl.handle.net/11054/2228 | - |
dc.description.abstract | Background In medically refractory Ulcerative Colitis (UC), proctocolectomy with ileoanal pouch procedure (IAPP) is the preferred continence-preserving surgical option. Functional outcomes post-surgery and long-term complication rates in the biologic era remain ambiguous. This review primarily aims to provide an update on these outcomes. Secondarily, risk factors associated with chronic pouchitis and pouch failure are explored. Methods Two online databases (MEDLINE and EMBASE) were searched on 4 October 2022 for English studies from 2011-present relating to long-term outcomes of IAPP in inflammatory bowel disease (IBD) patients. Adult patients with 12 month follow-up were included. Studies focused on 30-day post-operative outcomes, non-IBD patients or studies including less than 30 patients were excluded. Results Following screening and full-text review of 1094 studies, 49 were included. Median sample size was n = 282 (IQR: 116–519). Median incidences for chronic pouchitis and pouch failure were 17.1% (IQR: 12–23.6%) and 6.9% (IQR: 4.8–10.8%), respectively. Upon multivariate analysis, chronic pouchitis development was most significantly associated with pre-operative steroid use, pancolitis and extra-intestinal IBD manifestations, whilst pouch failure was most significantly associated with pre-operative diagnosis of Crohn's disease (compared to UC), peri-operative pelvic sepsis and anastomotic leak. Overall patient satisfaction was very high with four included studies reporting greater than 90% satisfaction rates. Conclusion Long-term complications for IAPP were common. However, despite this, patient satisfaction post-IAPP was high. Up-to-date knowledge of complication rates and their risk factors improves pre-operative counselling, management planning and patient outcomes. | en_US |
dc.description.provenance | Submitted by Gemma Siemensma (gemmas@bhs.org.au) on 2023-08-04T06:15:25Z No. of bitstreams: 0 | en |
dc.description.provenance | Approved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2023-08-08T11:03:44Z (GMT) No. of bitstreams: 0 | en |
dc.description.provenance | Made available in DSpace on 2023-08-08T11:03:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2023 | en |
dc.title | Review of long-term complications and functional outcomes of ileoanal pouch procedures in patients with inflammatory bowel disease. | en_US |
dc.type | Journal Article | en_US |
dc.type.specified | Article | en_US |
dc.bibliographicCitation.title | ANZ Journal of Surgery | en_US |
dc.bibliographicCitation.volume | 93 | en_US |
dc.bibliographicCitation.issue | 6 | en_US |
dc.bibliographicCitation.stpage | 1503 | en_US |
dc.bibliographicCitation.endpage | 1509 | en_US |
dc.subject.healththesaurus | CROHN'S DISEASE | en_US |
dc.subject.healththesaurus | ILEOANAL POUCHES | en_US |
dc.subject.healththesaurus | INFLAMMATORY BOWEL DISEASE | en_US |
dc.subject.healththesaurus | POUCH FAILURE | en_US |
dc.subject.healththesaurus | POUCH FISTULA | en_US |
dc.subject.healththesaurus | POUCHITIS | en_US |
dc.subject.healththesaurus | ULCERATIVE COLITIS | en_US |
dc.identifier.doi | https://doi.org/10.1111/ans.18490 | en_US |
Appears in Collections: | Research Output |
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