Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/2228
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dc.contributorHassan, Y.en_US
dc.contributorConnell, W.en_US
dc.contributorRawal, Alishaen_US
dc.contributorWright, E.en_US
dc.date.accessioned2023-08-08T11:03:44Z-
dc.date.available2023-08-08T11:03:44Z-
dc.date.issued2023-
dc.identifier.govdoc02260en_US
dc.identifier.urihttp://hdl.handle.net/11054/2228-
dc.description.abstractBackground In medically refractory Ulcerative Colitis (UC), proctocolectomy with ileoanal pouch procedure (IAPP) is the preferred continence-preserving surgical option. Functional outcomes post-surgery and long-term complication rates in the biologic era remain ambiguous. This review primarily aims to provide an update on these outcomes. Secondarily, risk factors associated with chronic pouchitis and pouch failure are explored. Methods Two online databases (MEDLINE and EMBASE) were searched on 4 October 2022 for English studies from 2011-present relating to long-term outcomes of IAPP in inflammatory bowel disease (IBD) patients. Adult patients with 12 month follow-up were included. Studies focused on 30-day post-operative outcomes, non-IBD patients or studies including less than 30 patients were excluded. Results Following screening and full-text review of 1094 studies, 49 were included. Median sample size was n = 282 (IQR: 116–519). Median incidences for chronic pouchitis and pouch failure were 17.1% (IQR: 12–23.6%) and 6.9% (IQR: 4.8–10.8%), respectively. Upon multivariate analysis, chronic pouchitis development was most significantly associated with pre-operative steroid use, pancolitis and extra-intestinal IBD manifestations, whilst pouch failure was most significantly associated with pre-operative diagnosis of Crohn's disease (compared to UC), peri-operative pelvic sepsis and anastomotic leak. Overall patient satisfaction was very high with four included studies reporting greater than 90% satisfaction rates. Conclusion Long-term complications for IAPP were common. However, despite this, patient satisfaction post-IAPP was high. Up-to-date knowledge of complication rates and their risk factors improves pre-operative counselling, management planning and patient outcomes.en_US
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2023-08-04T06:15:25Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2023-08-08T11:03:44Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2023-08-08T11:03:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2023en
dc.titleReview of long-term complications and functional outcomes of ileoanal pouch procedures in patients with inflammatory bowel disease.en_US
dc.typeJournal Articleen_US
dc.type.specifiedArticleen_US
dc.bibliographicCitation.titleANZ Journal of Surgeryen_US
dc.bibliographicCitation.volume93en_US
dc.bibliographicCitation.issue6en_US
dc.bibliographicCitation.stpage1503en_US
dc.bibliographicCitation.endpage1509en_US
dc.subject.healththesaurusCROHN'S DISEASEen_US
dc.subject.healththesaurusILEOANAL POUCHESen_US
dc.subject.healththesaurusINFLAMMATORY BOWEL DISEASEen_US
dc.subject.healththesaurusPOUCH FAILUREen_US
dc.subject.healththesaurusPOUCH FISTULAen_US
dc.subject.healththesaurusPOUCHITISen_US
dc.subject.healththesaurusULCERATIVE COLITISen_US
dc.identifier.doihttps://doi.org/10.1111/ans.18490en_US
Appears in Collections:Research Output

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