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http://hdl.handle.net/11054/2211
Title: | Systemic sclerosis following COVID-19 infection with recurrent corticosteroid-induced scleroderma renal crisis. |
Author: | Carroll, Mitchell Nagarajah, Vanitha Campbell, Sian |
Issue Date: | 2023 |
Publication Title: | BMJ Case Report |
Volume: | 16 |
Issue: | 3 |
Start Page: | e253735 |
Abstract: | Systemic sclerosis is a complex multisystem connective tissue disease resulting in fibrosis of the skin and internal organs. Exposure to corticosteroids can trigger scleroderma renal crisis, a life-threatening complication of the disease. Autoimmune disease following infection with COVID-19 is being increasingly recognised. The mechanisms of post-COVID-19 autoimmunity are likely multifactorial, involving immune dysregulation, molecular mimicry and the development of cross-reactive antibodies. There are currently only two reported cases of systemic sclerosis occurring post-COVID-19 infection.We present the case of a female patient who developed systemic sclerosis post-COVID-19 infection. Following exposure to corticosteroids, the patient developed scleroderma renal crisis complicated by thrombotic microangiopathy, seizures and acute renal failure. Despite an antibody profile not typically associated with renal crisis (anti-topoisomerase positive, anti-RNA-polymerase III negative), the patient developed recurrent renal crisis with repeated exposure to corticosteroid therapy, highlighting the risk of steroid use in all patients with systemic sclerosis. |
URI: | http://hdl.handle.net/11054/2211 |
DOI: | https://doi.org/10.1136/bcr-2022-253735 |
Internal ID Number: | 02131 |
Health Subject: | ACUTE RENAL FAILURE COVID-19 CONNECTIVE TISSUE DISEASE CONTRAINDICATIONS AND PRECAUTIONS |
Type: | Journal Article Article |
Appears in Collections: | Research Output |
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