Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/2211
Title: Systemic sclerosis following COVID-19 infection with recurrent corticosteroid-induced scleroderma renal crisis.
Author: Carroll, Mitchell
Nagarajah, Vanitha
Campbell, Sian
Issue Date: 2023
Publication Title: BMJ Case Report
Volume: 16
Issue: 3
Start Page: e253735
Abstract: Systemic sclerosis is a complex multisystem connective tissue disease resulting in fibrosis of the skin and internal organs. Exposure to corticosteroids can trigger scleroderma renal crisis, a life-threatening complication of the disease. Autoimmune disease following infection with COVID-19 is being increasingly recognised. The mechanisms of post-COVID-19 autoimmunity are likely multifactorial, involving immune dysregulation, molecular mimicry and the development of cross-reactive antibodies. There are currently only two reported cases of systemic sclerosis occurring post-COVID-19 infection.We present the case of a female patient who developed systemic sclerosis post-COVID-19 infection. Following exposure to corticosteroids, the patient developed scleroderma renal crisis complicated by thrombotic microangiopathy, seizures and acute renal failure. Despite an antibody profile not typically associated with renal crisis (anti-topoisomerase positive, anti-RNA-polymerase III negative), the patient developed recurrent renal crisis with repeated exposure to corticosteroid therapy, highlighting the risk of steroid use in all patients with systemic sclerosis.
URI: http://hdl.handle.net/11054/2211
DOI: https://doi.org/10.1136/bcr-2022-253735
Internal ID Number: 02131
Health Subject: ACUTE RENAL FAILURE
COVID-19
CONNECTIVE TISSUE DISEASE
CONTRAINDICATIONS AND PRECAUTIONS
Type: Journal Article
Article
Appears in Collections:Research Output

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.