Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/2031
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dc.contributorPavlakis, N.en_US
dc.contributorTincknell, G.en_US
dc.contributorLim, Lisi Elizabethen_US
dc.contributorMuro, K.en_US
dc.contributorObermannova, R.en_US
dc.contributorLorenzen, S.en_US
dc.contributorChua, Y.en_US
dc.contributorJackson, C.en_US
dc.contributorKarapetis, C.en_US
dc.contributorPrice, T.en_US
dc.contributorChantrill, L.en_US
dc.contributorSegelov, E.en_US
dc.contributorLordick, F.en_US
dc.date.accessioned2022-12-16T02:52:00Z-
dc.date.available2022-12-16T02:52:00Z-
dc.date.issued2022-
dc.identifier.govdoc01953en_US
dc.identifier.urihttp://hdl.handle.net/11054/2031-
dc.description.abstractAbstract Gastric carcinoma and gastro-oesophageal junction (GC/GEJ) carcinoma remain a significant global problem, with patients presenting with symptoms often found to have advanced or metastatic disease. Treatment options for these patients have broadened in recent years with new chemotherapy agents, agents targeting angiogenic pathways and the development of immune checkpoint inhibitors (ICIs). Most initial advances have occurred in the refractory setting, where it is important to balance treatment benefits versus toxicity and patient quality of life. In the first-line treatment of advanced/metastatic GC/GEJ, platinum- and fluoropyrimidine-based chemotherapy protocols remain the backbone of therapy (with or without HER2-targeted therapy), with the FOLFIRI regimen offering an alternative in patients deemed unsuitable for a platinum agent. Microsatellite instability-high or mismatch repair-deficient cancers have been shown to benefit most from ICIs. In unselected patients previously treated with doublet or triplet platinum- and fluoropyrimidine-based chemotherapy and second-line chemotherapy with irinotecan or taxanes have formed the backbone of therapy with or without the addition of the vascular endothelial growth factor receptor-2 inhibitor ramucirumab in addition to paclitaxel. Beyond this, efficacy has been demonstrated with oral trifluridine/tipiracil and with single-agent nivolumab, in selected refractory patients. In this review, we highlight the positive evidence from key trials that have led to our current practice algorithm, with particular focus on the refractory advanced disease setting, discussing the areas of active research and highlighting the factors, including biomarkers and the influence of ethnicity, that contribute to therapeutic decision-making.en_US
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2022-11-25T03:03:54Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2022-12-16T02:52:00Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2022-12-16T02:52:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2022en
dc.titleEuropean-Australasian consensus on the management of advanced gastric and gastro-oesophageal junction cancer: current practice and new directions.en_US
dc.typeJournal Articleen_US
dc.type.specifiedArticleen_US
dc.bibliographicCitation.titleTherapeutic Advances in Medical Oncologyen_US
dc.bibliographicCitation.volume24en_US
dc.bibliographicCitation.issue14en_US
dc.bibliographicCitation.stpage1en_US
dc.subject.healththesaurusANTIANGIOGENESISen_US
dc.subject.healththesaurusCHEMOTHERAPYen_US
dc.subject.healththesaurusGASTRIC ADENOCARCINOMAen_US
dc.subject.healththesaurusGASTRO-OESOPHAGEAL JUNCTIONen_US
dc.subject.healththesaurusIMMUNE CHECKPOINT INHIBITORSen_US
dc.subject.healththesaurusREFRACTORY DISEASEen_US
dc.identifier.doihttps://doi.org/10.1177/175883592211188en_US
Appears in Collections:Research Output

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