Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/1979
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dc.contributorSeth, I.en_US
dc.contributorBulloch, G.en_US
dc.contributorSeth, N.en_US
dc.contributorSiu, A.en_US
dc.contributorClayton, S.en_US
dc.contributorLower, K.en_US
dc.contributorRoshan, S.en_US
dc.contributorNara, Naveenen_US
dc.date.accessioned2022-10-25T01:56:43Z-
dc.date.available2022-10-25T01:56:43Z-
dc.date.issued2022-
dc.identifier.govdoc01928en_US
dc.identifier.urihttp://hdl.handle.net/11054/1979-
dc.description.abstractAbstract Complex regional pain syndrome type 1 (CRPS-I) is a complex complication that occurs after limb extremity surgeries. Controversy exists regarding the effectiveness of vitamin C in reducing that condition. Therefore, we conducted this systematic review and meta-analysis to assess the role of vitamin C on CRPS-I and functional outcomes after distal radius, wrist, foot, and ankle surgeries. We searched Medline (via PubMed), Embase, the Cochrane Library, Clinicaltrial.gov, and Google Scholar for relevant studies comparing perioperative vitamin C versus placebo after distal radius, wrist, foot, and ankle surgeries from infinity to May 2021. Continuous data such as functional outcomes and pain scores were pooled as mean differences, while dichotomous variables such as the incidence of complex regional pain syndrome and complications were pooled as odds ratios, with 95% confidence interval, using R software (meta package, version 4.9-0) for Windows. Eight studies were included. The timeframe for vitamin C administration in each study ranged from 42 to 50 days postinjury and/or surgical fixation. The effect size showed that vitamin C was associated with a decreased rate of CRPS-1 than placebo (odds ratio 0.33, 95% confidence interval [0.17, 0.63]). No significant difference was found between vitamin C and placebo in terms of complications (odds ratio 1.90, 95% confidence interval [0.99, 3.65]), functional outcomes (mean difference 6.37, 95% confidence interval [-1.40, 14.15]), and pain scores (mean difference -0.14, 95% confidence interval [-1.07, 0.79]). Overall, vitamin C was associated with a decreased rate of CRPS-I than placebo, while no significant difference was found regarding complications, functional outcomes, and pain scores. These results hold true when stratifying fracture type (distal radius, ankle, and foot surgeries) and vitamin C dose (500 mg or 1 g).en_US
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2022-08-18T03:33:31Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2022-10-25T01:56:43Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2022-10-25T01:56:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2022en
dc.titleEffect of Perioperative Vitamin C on the Incidence of Complex Regional Pain Syndrome: A Systematic Review and Meta-Analysis.en_US
dc.typeJournal Articleen_US
dc.type.specifiedArticleen_US
dc.bibliographicCitation.titleThe Journal of Foot & Ankle Surgeryen_US
dc.bibliographicCitation.volume61en_US
dc.bibliographicCitation.issue4en_US
dc.bibliographicCitation.stpage748en_US
dc.bibliographicCitation.endpage754en_US
dc.subject.healththesaurusANKLEen_US
dc.subject.healththesaurusCOMPLEX REGIONAL PAIN SYNDROMEen_US
dc.subject.healththesaurusCRPS-Ien_US
dc.subject.healththesaurusDISTAL RADIUSen_US
dc.subject.healththesaurusFOOTen_US
dc.subject.healththesaurusVITAMIN Cen_US
dc.identifier.doihttps://doi.org/10.1053/j.jfas.2021.11.008en_US
Appears in Collections:Research Output

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