Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/1938
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dc.contributorFrawley, Natashaen_US
dc.contributorJones, Richarden_US
dc.contributorPearce, Doraen_US
dc.contributorVollenhoven, Beverleyen_US
dc.date.accessioned2022-06-01T06:55:26Z-
dc.date.available2022-06-01T06:55:26Z-
dc.date.issued2022-
dc.identifier.govdoc01886en_US
dc.identifier.urihttp://hdl.handle.net/11054/1938-
dc.description.abstractBackground: Intraperitoneal local anaesthetic has shown benefit in operative laparoscopy; however, no randomised controlled trial has been reported with patients having diagnostic laparoscopy. Aims: To determine the effect of intraperitoneal ropivacaine on post-operative analgesic requirements, pain, nausea scores and recovery following gynaecological diagnostic laparoscopy and hysteroscopy. Materials and methods: Randomised double-blind placebo-controlled trial. Well women aged 18-50 years, undergoing day case hysteroscopy and diagnostic laparoscopy for gynaecological indications were randomised to 20 mL of 150 mg intraperitoneal ropivacaine diluted in saline, or 20 mL normal saline instillation (placebo) at the end of the procedure. Women were followed up until eight hours post-discharge. Results: Slower than anticipated recruitment meant that the study was finished before the sample size of 100 patients was achieved. Fifty-nine patients were included for analysis. Thirty-one patients were randomised to ropivacaine and 28 patients to control. Sixty-one percent of patients in both arms required opioid medication in recovery. The total median equivalent morphine dose was significantly higher in the patients randomised to control (11.7 mg) vs ropivacaine (6.7 mg), P = 0.03. Time to discharge was 20 min faster in patients randomised to ropivacaine, but this finding did not reach significance. Overall pain and nausea scores in the first eight hours showed no significant differences. Conclusion: There was significantly reduced opioid use in recovery when using intraperitoneal ropivacaine compared to placebo, in this randomised placebo-controlled trial on women undergoing day case diagnostic laparoscopy and hysteroscopy.en_US
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2022-05-06T01:47:31Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2022-06-01T06:55:26Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2022-06-01T06:55:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2022en
dc.titleThe effect of intraperitoneal ropivacaine on post-operative pain and recovery after diagnostic laparoscopy and hysteroscopy: A randomised double-blind placebo-controlled trial.en_US
dc.typeJournal Articleen_US
dc.type.specifiedArticleen_US
dc.bibliographicCitation.titleAustralian & New Zealand Journal of Obstetrics & Gynaecologyen_US
dc.bibliographicCitation.volume62en_US
dc.bibliographicCitation.issue1en_US
dc.bibliographicCitation.stpage118en_US
dc.bibliographicCitation.endpage124en_US
dc.subject.healththesaurusLAPAROSCOPYen_US
dc.subject.healththesaurusLOCAL ANAESTHETICSen_US
dc.subject.healththesaurusPATIENT RECOVERYen_US
dc.subject.healththesaurusPOST-OPERATIVE NAUSEA AND VOMITINGen_US
dc.subject.healththesaurusPOST-OPERATIVE PAINen_US
dc.subject.healththesaurusRANDOMISED CONTROLLED TRIALen_US
dc.identifier.doihttps://doi.org/10.1111/ajo.13439en_US
Appears in Collections:Research Output

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