Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/1767
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dc.contributorPapapostolou, S.en_US
dc.contributorDinh, D.en_US
dc.contributorNoaman, S.en_US
dc.contributorBiswas, S.en_US
dc.contributorDuffy, S.en_US
dc.contributorStub, D.en_US
dc.contributorShaw, J.en_US
dc.contributorWalton, A.en_US
dc.contributorSharma, Ananden_US
dc.contributorBrennan, A.en_US
dc.contributorClark, D.en_US
dc.contributorFreeman, M.en_US
dc.contributorYip, T.en_US
dc.contributorAjani, A.en_US
dc.contributorReid, C.en_US
dc.contributorOqueli, Ernestoen_US
dc.contributorChan, W.en_US
dc.date.accessioned2021-10-04T00:50:59Z-
dc.date.available2021-10-04T00:50:59Z-
dc.date.issued2021-
dc.identifier.govdoc01721en_US
dc.identifier.urihttp://hdl.handle.net/11054/1767-
dc.description.abstractObjectives To evaluate the effect of age in an all-comers population undergoing percutaneous coronary intervention (PCI). Background Age is an important consideration in determining appropriateness for invasive cardiac assessment and perceived clinical outcomes. Methods We analysed data from 29,012 consecutive patients undergoing PCI in the Melbourne Interventional Group (MIG) registry between 2005 and 2017. 25,730 patients <80 year old (78% male, mean age 62±10 years; non-elderly cohort) were compared to 3,282 patients ≥80 year old (61% male, mean age 84±3 years; elderly cohort). Results The elderly cohort had greater prevalence of hypertension, diabetes and previous myocardial infarction (all p<0.001). Elderly patients were more likely to present with acute coronary syndromes, left ventricular ejection fraction <45% and chronic kidney disease (p<0.0001). In-hospital, 30-day and long-term all-cause mortality (over a median of 3.6 and 5.1 years for elderly and non-elderly cohorts, respectively) were higher in the elderly cohort (5.2% vs. 1.9%; 6.4% vs. 2.2%; and 43% vs. 14% respectively, all p<0.0001). In multivariate Cox regression analysis, estimated glomerular filtration rate (eGFR) <30 mL/min/1.73 m2 (HR 3.8, 95% CI: 3.4–4.3), cardiogenic shock (HR 3.0, 95% CI: 2.6–3.4), ejection fraction <30% (HR 2.5, 95% CI: 2.1–2.9); and age ≥80 years (HR 2.8, 95% CI: 2.6–3.1) were independent predictors of long-term all-cause mortality (all p<0.0001). Conclusion The elderly cohort is a high-risk group of patients with increasing age being associated with poorer long-term mortality. Age, thus, should be an important consideration when individualising treatment in elderly patients.en_US
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2021-08-06T04:22:31Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2021-10-04T00:50:59Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2021-10-04T00:50:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2021en
dc.titleEffect of age on clinical outcomes in elderly patients (>80 years) undergoing percutaneous coronary intervention: insights from a multi-centre Australian PCI registry.en_US
dc.typeJournal Articleen_US
dc.type.specifiedArticleen_US
dc.contributor.corpauthorMelbourne Interventional Group Investigatorsen_US
dc.bibliographicCitation.titleHeart, Lung and Circulationen_US
dc.bibliographicCitation.volume30en_US
dc.bibliographicCitation.issue7en_US
dc.bibliographicCitation.stpage1002en_US
dc.bibliographicCitation.endpage1013en_US
dc.subject.healththesaurusELDERLY OCTOGENARIANSen_US
dc.subject.healththesaurusPERCUTANEOUS CORONARY INTERVENTIONen_US
dc.subject.healththesaurusCORONARY ANGIOGRAPHYen_US
dc.identifier.doihttps://doi.org/10.1016/j.hlc.2020.12.003en_US
Appears in Collections:Research Output

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