Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/1725
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dc.contributorOkahara, S.en_US
dc.contributorSnell, G. I.en_US
dc.contributorMcDonald, M.en_US
dc.contributorD'Costa, R.en_US
dc.contributorOpdam, H.en_US
dc.contributorPilcher, D. V.en_US
dc.contributorLevvey, B.en_US
dc.date.accessioned2021-07-14T03:33:25Z-
dc.date.available2021-07-14T03:33:25Z-
dc.date.issued2021-
dc.identifier.govdoc01713en_US
dc.identifier.urihttp://hdl.handle.net/11054/1725-
dc.descriptionIncludes data from BHSen_US
dc.description.abstractAlthough the use of donation after circulatory death (DCD) donors has increased lung transplant activity, 25-40% of intended DCD donors do not convert to actual donation because of no progression to asystole in the required time frame after withdrawal of cardiorespiratory support (WCRS). No studies have specifically focussed on DCD lung donor progression. This retrospective study reviewed intended DCD lung donors to make a prediction model of the likelihood of progression to death using logistic regression and classification and regression tree (CART). Between 2014 and 2018, 159 of 334 referred DCD donors were accepted, with 100 progressing to transplant, while 59 (37%) did not progress. In logistic regression, a length of ICU stay ≤ 5 days, severe infra-tentorial brain damage on imaging and use of vasopressin were related with the progression to actual donation. CART modelling of the likelihood of death within 90-minute post-WCRS provided prediction with a sensitivity of 1.00 and positive predictive value of 0.56 in the validation data set. In the nonprogressed DCD group, 26 died within 6 h post-WCRS. Referral received early after ICU admission, with nonspontaneous ventilatory mode, deep coma and severe infra-tentorial damage were relevant predictors. The CART model is useful to exclude DCD donor candidates with low probability of progression.en_US
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2021-06-10T03:20:16Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2021-07-14T03:33:25Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2021-07-14T03:33:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2021en
dc.titleImproving the predictability of time to death in controlled donation after circulatory death lung donors.en_US
dc.typeJournal Articleen_US
dc.type.specifiedArticleen_US
dc.bibliographicCitation.titleTransplant Internationalen_US
dc.bibliographicCitation.volume34en_US
dc.bibliographicCitation.issue5en_US
dc.bibliographicCitation.stpage906en_US
dc.bibliographicCitation.endpage915en_US
dc.subject.healththesaurusDONATION AFTER CIRCULATORY DEATHen_US
dc.subject.healththesaurusLUNG TRANSPLANTen_US
dc.subject.healththesaurusORGAN DONATIONen_US
dc.subject.healththesaurusPROGRESSION WITHIN TIME FRAMEen_US
dc.identifier.doihttps://doi.org/10.1111/tri.13862en_US
Appears in Collections:Research Output

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