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dc.contributorHughes, A. M.en_US
dc.contributorPonsonby, A. -L.en_US
dc.contributorDear, K.en_US
dc.contributorDwyer, T.en_US
dc.contributorTaylor, B. V.en_US
dc.contributorvan der Mei, I.en_US
dc.contributorValery, P. C.en_US
dc.contributorAusimmune Investigator Groupen_US
dc.contributorLucas, R. M.en_US
dc.descriptionIncludes BHS data.en_US
dc.description.abstractBackground The association between childhood vaccinations and infections and risk of multiple sclerosis is unclear; few studies have considered age at vaccination/infection. Objective To explore age-related associations between childhood vaccinations, infection and tonsillectomy and risk of a first clinical diagnosis of CNS demyelination. Methods Data on case (n = 275, 76.6% female; mean age 38.6 years) and age- and sex-matched control (n = 529) participants in an incident population-based case-control study included self-reported age at time of childhood vaccinations, infections, and tonsillectomy. Conditional logistic regression models were used to calculate adjusted odds ratios (AOR) and 95% confidence intervals (CI). Results Poliomyelitis vaccination prior to school-age was associated with increased risk of a first clinical diagnosis of CNS demyelination (AOR = 2.60, 95%CI 1.02–6.68), based on a very small unvaccinated reference group. Late (11–15 years) rubella vaccination (compared to none) was associated with lower odds of being a case (AOR = 0.47, 95%CI 0.27–0.83). Past infectious mononucleosis at 11–15 years (AOR = 2.84, 95%CI 1.0–7.57) and 16–20 years (AOR = 1.92, 95%CI 1.12–3.27) or tonsillectomy in adolescence (11–15 years: AOR = 2.45, 95%CI 1.12–5.35), including after adjustment for IM, were associated with increased risk of a first clinical diagnosis of CNS demyelination. Conclusions Age at vaccination, infection or tonsillectomy may alter the risk of subsequent CNS demyelination. Failing to account for age effects may explain inconsistencies in past findings.en_US
dc.description.provenanceSubmitted by Gemma Siemensma ( on 2020-10-13T03:08:39Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma ( on 2020-11-23T05:49:55Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-11-23T05:49:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2020en
dc.titleChildhood infections, vaccinations, and tonsillectomy and risk of first clinical diagnosis of CNS demyelination in the Ausimmune Study.en_US
dc.typeJournal Articleen_US
dc.bibliographicCitation.titleMultiple Sclerosis and Related Disordersen_US
dc.subject.healththesaurusMULTIPLE SCLEROSISen_US
dc.subject.healththesaurusCASE CONTROL STUDYen_US
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