Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/1462
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dc.contributorBiswas, S.en_US
dc.contributorAndrianopoulos, N.en_US
dc.contributorDinh, D.en_US
dc.contributorDuffy, S.en_US
dc.contributorLeftkovits, J.en_US
dc.contributorBrennan, Aen_US
dc.contributorNoaman, S.en_US
dc.contributorAjani, A.en_US
dc.contributorClark, D.en_US
dc.contributorFreeman, M.en_US
dc.contributorOqueli, Ernestoen_US
dc.contributorHiew, C.en_US
dc.contributorReid, C.en_US
dc.contributorStub, D.en_US
dc.contributorChan, W.en_US
dc.date.accessioned2020-01-08T03:50:55Z-
dc.date.available2020-01-08T03:50:55Z-
dc.date.issued2019-
dc.identifier.govdoc01442en_US
dc.identifier.urihttp://hdl.handle.net/11054/1462-
dc.description.abstractBackground Previous studies have reported a protective effect of obesity compared with normal body mass index (BMI) in patients undergoing percutaneous coronary intervention (PCI). However, it is unclear whether this effect extends to the extremely obese. In this large multicenter registry‐based study, we sought to examine the relationship between BMI and long‐term clinical outcomes following PCI, and in particular to evaluate the association between extreme obesity and long‐term survival after PCI. Methods and Results This cohort study included 25 413 patients who underwent PCI between January 1, 2005 and June 30, 2017, who were prospectively enrolled in the Melbourne Interventional Group registry. Patients were stratified by World Health Organization–defined BMI categories. The primary end point was National Death Index–linked mortality. The median length of follow‐up was 4.4 years (interquartile range 2.0‐7.6 years). Of the study cohort, 24.8% had normal BMI (18.5‐24.9 kg/m2), and 3.3% were extremely obese (BMI ≥40 kg/m2). Patients with greater degrees of obesity were younger and included a higher proportion of diabetics (P<0.001). After adjustment for age and comorbidities, a J‐shaped association was observed between different BMI categories and adjusted hazard ratio (HR) for long‐term mortality (normal BMI, HR 1.00 [ref]; overweight, HR 0.85, 95% CI 0.78‐0.93, P<0.001; mild obesity, HR 0.85, 95% CI 0.76‐0.94, P=0.002; moderate obesity, HR 0.95, 95% CI 0.80‐1.12, P=0.54; extreme obesity HR 1.33, 95% CI 1.07‐1.65, P=0.01). Conclusions An obesity paradox is still apparent in contemporary practice, with elevated BMI up to 35 kg/m2 associated with reduced long‐term mortality after PCI. However, this protective effect appears not to extend to patients with extreme obesity.en_US
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2019-12-17T05:18:09Z No. of bitstreams: 1 Association of body mass index and extreme obesity with long_term outcomes following percutaneous coronary intervention..pdf: 533643 bytes, checksum: 8f5b26da556ec8dd376bc48c282b6348 (MD5)en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2020-01-08T03:50:55Z (GMT) No. of bitstreams: 1 Association of body mass index and extreme obesity with long_term outcomes following percutaneous coronary intervention..pdf: 533643 bytes, checksum: 8f5b26da556ec8dd376bc48c282b6348 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-01-08T03:50:55Z (GMT). No. of bitstreams: 1 Association of body mass index and extreme obesity with long_term outcomes following percutaneous coronary intervention..pdf: 533643 bytes, checksum: 8f5b26da556ec8dd376bc48c282b6348 (MD5) Previous issue date: 2019en
dc.relation.urihttps://ahajournals.org/doi/full/10.1161/JAHA.119.012860en_US
dc.titleAssociation of body mass index and extreme obesity with long‐term outcomes following percutaneous coronary intervention.en_US
dc.typeJournal Articleen_US
dc.type.specifiedArticleen_US
dc.bibliographicCitation.titleJournal of the American Heart Associationen_US
dc.bibliographicCitation.volume8en_US
dc.bibliographicCitation.issue21en_US
dc.bibliographicCitation.stpagee012860en_US
dc.subject.healththesaurusLONG-TERM OUTCOMEen_US
dc.subject.healththesaurusOBESITYen_US
dc.subject.healththesaurusPERCUTANEOUS CORONARY INTERVENTIONen_US
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