Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/133
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dc.contributor.authorPeach, Hedley G.en
dc.contributor.authorBarnett, Nicole E.en
dc.date.accessioned2013-01-08T01:24:39Zen
dc.date.available2013-01-08T01:24:39Zen
dc.date.issued2001en
dc.identifier.govdoc00117en
dc.identifier.issn0278-0232en
dc.identifier.urihttp://hdl.handle.net/11054/133en
dc.description.abstractSmoking has been suggested to increase the risk of non-Hodgkin's lymphoma (NHL) but the results of epidemiological studies have been inconsistent. The aim of this work was to assess whether the findings of individual studies might have arisen by chance, bias or confounding and whether any associations found between smoking and NHL represent cause-and-effect. Reports of the association between smoking and NHL were identified from Medline. Confidence intervals on relative risks and odds ratios, use of multiple comparisons, and information on source, direction, actual existence and size of potential biases and confounding and features of any associations were abstracted. Four out of five cohort studies found no association between current smoking and NHL but three may have been biased against doing so. One found an association with follicular lymphoma but without a convincing exposure–risk gradient. The fifth found a strong association and an exposure–response gradient with ever smoking but excluded living cases from the end-point. Only one study found an association with past smoking which lacked features of causality. Eight out of 14 case–control studies found no association between current and/or past smoking and NHL but five may have been biased against doing so. Of six positive studies, three involved multiple comparisons, the association of one became non-significant after eliminating bias, four did not explore features of causality and one found an association only in heavy smokers, particularly under 45 years old. There are no grounds to reject the null hypothesis but associations should continue to be sought particularly in subgroups of smokers and with NHL subtypes.en
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2013-01-08T01:24:28Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2013-01-08T01:24:39Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2013-01-08T01:24:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2001en
dc.publisherWileyen
dc.relation.urihttp://onlinelibrary.wiley.com/doi/10.1002/hon.677/abstracten
dc.titleCritical review of epidemiological studies of the association between smoking and non-hodgkin's lymphoma.en
dc.typeJournal Articleen
dc.type.specifiedArticleen
dc.bibliographicCitation.titleHematological Oncologyen
dc.bibliographicCitation.volume19en
dc.bibliographicCitation.issue2en
dc.bibliographicCitation.stpage67-80en
dc.publisher.placeLondonen
dc.subject.healththesaurusNON-HODGKIN'S LYMPHOMAen
dc.subject.healththesaurusSMOKINGen
dc.subject.healththesaurusEPIDEMIOLOGYen
dc.subject.healththesaurusNHLen
dc.date.issuedbrowse2001-01-01en
Appears in Collections:Research Output

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