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dc.contributorHurley, James C.en_US
dc.description.abstractPurpose The objective here is to define the extent and possible reasons for geographic variation in Pseudomonas aeruginosa associated with Ventilator Associated Pneumonia (VAP). Methods A random effects meta-regression model of Pseudomonas associated VAP incidence within the published literature was undertaken incorporating group level factors such trauma admission, year of publication and use of bronchoscopic sampling towards VAP diagnosis. Results Pseudomonas associated VAP incidence was reported in 162 studies from seven worldwide regions published over 30 years. The highest incidence is among reports from the Middle East and Mediterranean being respectively 6.8; 5.2–9.0 (mean; 95% CI) and 6.9; 5.4–8.8 per 1000 mechanical ventilation (MV) days, versus that from North American ICU's (3.7; 2.3–5.9). In a meta-regression model, the variation in the incidence of Pseudomonas associated VAP was not significantly associated with bronchoscopic sampling in the diagnosis of VAP (p = 0.12) nor with admission to a trauma ICU (p = 0.13). Conclusion Pseudomonas associated VAP incidence among reports from six geographic regions worldwide varies by less than twofold with some decline by year of publication. Trauma ICU admission is a significant factor underlying variations in incidence of VAP overall but not Pseudomonas associated VAP.en_US
dc.description.provenanceSubmitted by Gemma Siemensma ( on 2019-04-01T04:40:41Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma ( on 2019-04-05T00:00:47Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2019-04-05T00:00:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.titleWorldwide variation in pseudomonas associated ventilator associated pneumonia. A meta-regression.en_US
dc.typeJournal Articleen_US
dc.bibliographicCitation.titleJournal of Critical Careen_US
dc.subject.healththesaurusINTENSIVE CARE UNITen_US
dc.subject.healththesaurusGEOGRAPHIC VARIATIONen_US
dc.subject.healththesaurusVENTILATOR ASSOCIATED PNEUMONIAen_US
dc.subject.healththesaurusPSEUDOMONAS AERUGINOSAen_US
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