Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/216
Title: Symptom relief with amitriptyline in the Irritable Bowel syndrome.
Authors: Rajagopalan, Mani
Kurian, George
John, Jacob
Issue Date: 1998
Publisher: Wiley
Place of publication: London
Journal title: Journal of Gastroenterology and Hepatology
Volume: 13
Issue: 7
Start Page: 738
End Page: 741
Abstract: Anti-depressants have been reported to be useful in the management of the Irritable Bowel syndrome. We studied the efficacy of amitriptyline for 12 weeks in a randomized double-blind placebocontrolled trial. Forty patients who met predefined criteria entered the trial. They received 25 mg amitriptyline for the first week, 50 mg for the second week and 75 mg nightly thereafter until the end of the 12th week. The drug and placebo groups were comparable in all major pretreatment variables. Amitriptyline was found to be significantly more effective than placebo in producing global improvement, increasing feelings of well-being, reducing abdominal pain and increasing satisfaction with bowel movements. Younger age and increasing extroversion predicted a better response to amitriptyline. Severity of depressive and anxiety symptoms and other personality variables did not influence outcome.
URI: http://hdl.handle.net/11054/216
metadata.dc.relation.uri: http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.1998.tb00723.x/abstract
ISSN: 0815-9319
Internal ID Number: 00200
Health Subject: AMITRIPTYLINE
COLON
COLONIC DISEASES
IRRITABLE BOWEL SYNDROME
IBS
PLACEBO
ANTI-DEPRESSANT
Type: Journal Article
Article
Appears in Collections:Research Output

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