Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/902
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dc.contributor.authorNoaman, Samer*
dc.contributor.authorIbrahim, Joseph E.*
dc.contributor.authorGrenfell, Robert*
dc.date.accessioned2016-08-09T05:06:45Z-
dc.date.available2016-08-09T05:06:45Z-
dc.date.issued2014en
dc.identifier.govdoc00718en
dc.identifier.issn1443-9506en
dc.identifier.urihttp://hdl.handle.net/11054/902-
dc.description.abstractAustralia's oldest old are potentially being harmed by the under- and over- use of statins. Variations in prescription of statins are in part due to the vacuum of clinical research trial evidence and paucity of contemporary guidelines that are needed to address the use of lipid lowering therapy in the oldest old. There are a few randomised placebo-controlled trials that recruited an older population. Therefore evidence of statins efficacy in the oldest old is based on an extrapolation of results from those studies. The extensive exclusion criteria of those studies, the relative youth of the study participants, the low levels of comorbidity and functional impairment limit the external validity and the generalisability of the findings. Current guidelines are silent or generally non-specific about statin therapy for the oldest old deferring decisions to individual medical practitioners. Life expectancy, time to benefit, functional status and medication related adverse events, polypharmacy, adherence to treatment are factors that need to be considered when forming appropriate guidelines for statin prescription in the very old. Well-designed clinical trials that account for the heterogeneity of this population are needed. While waiting for this research evidence better clinical guidelines are needed to address this issue.en
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2015-07-23T08:19:20Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2016-08-09T05:06:45Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2016-08-09T05:06:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.publisherElsevieren
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S1443950614001176en
dc.titlePrescribing statins for cardiovascular disease prevention in the old: an absence of evidence and an absence of guidelines.en
dc.typeJournal Article*
dc.type.specifiedArticleen
dc.bibliographicCitation.titleHeart, Lung & Circulationen
dc.bibliographicCitation.volume23en
dc.bibliographicCitation.issue7en
dc.bibliographicCitation.stpage619en
dc.bibliographicCitation.endpage624en
dc.publisher.placeAtlanta, GAen
dc.subject.healththesaurusAGED, 80 AND OVERen
dc.subject.healththesaurusCARDIOVASCULAR DISEASEen
dc.subject.healththesaurusELDERLYen
dc.subject.healththesaurusHEALTH SERVICES NEEDS AND DEMANDen
dc.subject.healththesaurusOLDER PEOPLEen
dc.subject.healththesaurusLIPIDSen
dc.subject.healththesaurusPRESCRIBINGen
dc.subject.healththesaurusSTATINSen
dc.date.issuedbrowse2014-01-01en
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