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Title: | Accelerated rejection of nematospiroides dubius intestinal worms in mice sensitized with adult worms. |
Authors: | Hurley, James C. Day, K. P. Mitchell, G. F. |
Issue Date: | 1980 |
Publisher: | University of Adelaide |
Place of publication: | Adelaide |
Publication Title: | The Australian Journal of Experimental Biology and Medical Science Immunology and Cell Biology |
Volume: | 58 |
Issue: | 3 |
Start Page: | 231 |
End Page: | 240 |
Abstract: | After oral administration of infective third stage larvae (L3) of Nematospiroides dubius to young mice, intestinal worms persist for many weeks. However, in mice injected parenterally with N. dubius adult worms, the intraluminal intestinal infection arising after L3 administration can be terminated within 3 to 4 weeks. This accelerated rejection is seen in sensitized BALB/c mice (and (CBA/H X BALB/c)F1 mice) and in particular females, but has not been demonstrated in sensitized CBA/H mice. In female BALB/c mice, small numbers of living worms are more effective at sensitization than dead worms, intraperitoneal and subcutaneous implantations are both effective, and products from adult worms incubated in vitro (i.e. "excretory/secretory" (ES) products) will sensitize but only with very high doses in adjuvant. Using appropriate isolated antigen preparations, comparative immunoparasitological analyses in different mice should provide clues on the nature of host-protective immunities against intestinal nematode infections which are potentially chronic. From the present studies, two groups which differ most dramatically in the consequences of adult worm sensitization are young male CBA/H versus older female BALB/c mice. |
URI: | http://hdl.handle.net/11054/50 |
ISSN: | 0004-945X |
Internal ID Number: | 00037 |
Health Subject: | ANIMALS ANTIGENS - IMMUNOLOGY ANTIGENS - ISOLATION AND PURIFICATION FEMALE IMMUNITY IMMUNISATION INTESTINAL DISEASES LARVA MALE MICE ANTIGENS TIME FACTORS NEMATODE INFECTIONS - IMMUNOLOGY INTESTINES - PARASITOLOGY |
Type: | Journal Article Article |
Appears in Collections: | Research Output |
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