Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/50
Title: Accelerated rejection of nematospiroides dubius intestinal worms in mice sensitized with adult worms.
Authors: Hurley, James C.
Day, K. P.
Mitchell, G. F.
Issue Date: 1980
Publisher: University of Adelaide
Place of publication: Adelaide
Publication Title: The Australian Journal of Experimental Biology and Medical Science
Immunology and Cell Biology
Volume: 58
Issue: 3
Start Page: 231
End Page: 240
Abstract: After oral administration of infective third stage larvae (L3) of Nematospiroides dubius to young mice, intestinal worms persist for many weeks. However, in mice injected parenterally with N. dubius adult worms, the intraluminal intestinal infection arising after L3 administration can be terminated within 3 to 4 weeks. This accelerated rejection is seen in sensitized BALB/c mice (and (CBA/H X BALB/c)F1 mice) and in particular females, but has not been demonstrated in sensitized CBA/H mice. In female BALB/c mice, small numbers of living worms are more effective at sensitization than dead worms, intraperitoneal and subcutaneous implantations are both effective, and products from adult worms incubated in vitro (i.e. "excretory/secretory" (ES) products) will sensitize but only with very high doses in adjuvant. Using appropriate isolated antigen preparations, comparative immunoparasitological analyses in different mice should provide clues on the nature of host-protective immunities against intestinal nematode infections which are potentially chronic. From the present studies, two groups which differ most dramatically in the consequences of adult worm sensitization are young male CBA/H versus older female BALB/c mice.
URI: http://hdl.handle.net/11054/50
ISSN: 0004-945X
Internal ID Number: 00037
Health Subject: ANIMALS
ANTIGENS - IMMUNOLOGY
ANTIGENS - ISOLATION AND PURIFICATION
FEMALE
IMMUNITY
IMMUNISATION
INTESTINAL DISEASES
LARVA
MALE
MICE
ANTIGENS
TIME FACTORS
NEMATODE INFECTIONS - IMMUNOLOGY
INTESTINES - PARASITOLOGY
Type: Journal Article
Article
Appears in Collections:Research Output

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