Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/39
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dc.contributor.authorHurley, James C.en
dc.date.accessioned2012-10-16T03:06:19Zen
dc.date.available2012-10-16T03:06:19Zen
dc.date.issued1995en
dc.identifier.govdoc00026en
dc.identifier.issn0095-1137en
dc.identifier.urihttp://hdl.handle.net/11054/39en
dc.description.abstractAmong patients with suspected sepsis, endotoxemia is variably present in association with gram-negative bacteremia. A total of 738 patients with suspected sepsis from 11 studies could be classified into four groups: 131 (18%) patients had both endotoxemia and gram-negative bacteremia (group 1), 87 (12%) had only gram-negative bacteremia (group 2), and 143 (19%) had only endotoxemia (group 3); in 377 (51%) patients neither could be detected (group 4). By the statistical techniques of meta-analysis, the fatality risk for patients with either endotoxemia or gram-negative bacteremia or both was estimated with group-specific case fatality rates from these studies and expressed as an odds ratio (OR; 95% confidence interval [95% CI]) versus patients with these factors absent. This risk was increased marginally when endotoxemia was detected without gram-negative bacteremia (OR, 2.3; 95% CI, 1.3 to 4.0) or the converse (OR, 2.0; 95% CI, 1.0 to 3.8), in contrast to the striking increase when both endotoxemia and gram-negative bacteremia were detected (OR, 6.3; 95% CI, 4.0 to 10.0). Alone, neither endotoxemia nor gram-negative bacteremia is a strong predictor of outcome in patients with suspected sepsis. However, in combination, the two identify a subpopulation with a substantially increased risk of mortality.en
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2012-10-16T03:06:03Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2012-10-16T03:06:19Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2012-10-16T03:06:19Z (GMT). No. of bitstreams: 0 Previous issue date: 1995en
dc.publisherAmerican Society for Microbiology.en
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC228145/en
dc.titleReappraisal with meta-analysis of bacteremia, endotoxemia, and mortality in gram-negative sepsis.en
dc.typeJournal Articleen
dc.type.specifiedArticleen
dc.bibliographicCitation.titleJournal of Clinical Microbiologyen
dc.bibliographicCitation.volume33en
dc.bibliographicCitation.issue5en
dc.bibliographicCitation.stpage1278en
dc.bibliographicCitation.endpage1282en
dc.publisher.placeWashingtonen
dc.subject.healththesaurusMETA ANALYSISen
dc.subject.healththesaurusADOLESCENTen
dc.subject.healththesaurusADULTen
dc.subject.healththesaurusAGEDen
dc.subject.healththesaurusBACTEREMIA - COMPLICATIONSen
dc.subject.healththesaurusBACTEREMIA - MORTALITYen
dc.subject.healththesaurusCHILDen
dc.subject.healththesaurusCHILD - PRESCHOOLen
dc.subject.healththesaurusENDOTOXINS - BLOODen
dc.subject.healththesaurusGRAM NEGATIVE BACTERIAL INFECTIONS - COMPLICATIONSen
dc.subject.healththesaurusGRAM NEGATIVE BACTERIAL INFECTIONS - MORTALITYen
dc.subject.healththesaurusHUMANSen
dc.subject.healththesaurusINFANTen
dc.subject.healththesaurusMIDDLE AGEDen
dc.subject.healththesaurusODDS RATIOen
dc.subject.healththesaurusPROGNOSISen
dc.subject.healththesaurusRISK FACTORSen
dc.subject.healththesaurusSEPSIS - COMPLICATIONSen
dc.subject.healththesaurusSEPSIS - MORTALITYen
dc.subject.healththesaurusTOXEMIA - COMPLICATIONSen
dc.subject.healththesaurusTOXEMIA - MORTALITYen
dc.subject.healththesaurusENDOTOXINSen
dc.date.issuedbrowse1995-01-01en
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