Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/39
Title: Reappraisal with meta-analysis of bacteremia, endotoxemia, and mortality in gram-negative sepsis.
Authors: Hurley, James C.
Issue Date: 1995
Publisher: American Society for Microbiology.
Place of publication: Washington
Publication Title: Journal of Clinical Microbiology
Volume: 33
Issue: 5
Start Page: 1278
End Page: 1282
Abstract: Among patients with suspected sepsis, endotoxemia is variably present in association with gram-negative bacteremia. A total of 738 patients with suspected sepsis from 11 studies could be classified into four groups: 131 (18%) patients had both endotoxemia and gram-negative bacteremia (group 1), 87 (12%) had only gram-negative bacteremia (group 2), and 143 (19%) had only endotoxemia (group 3); in 377 (51%) patients neither could be detected (group 4). By the statistical techniques of meta-analysis, the fatality risk for patients with either endotoxemia or gram-negative bacteremia or both was estimated with group-specific case fatality rates from these studies and expressed as an odds ratio (OR; 95% confidence interval [95% CI]) versus patients with these factors absent. This risk was increased marginally when endotoxemia was detected without gram-negative bacteremia (OR, 2.3; 95% CI, 1.3 to 4.0) or the converse (OR, 2.0; 95% CI, 1.0 to 3.8), in contrast to the striking increase when both endotoxemia and gram-negative bacteremia were detected (OR, 6.3; 95% CI, 4.0 to 10.0). Alone, neither endotoxemia nor gram-negative bacteremia is a strong predictor of outcome in patients with suspected sepsis. However, in combination, the two identify a subpopulation with a substantially increased risk of mortality.
URI: http://hdl.handle.net/11054/39
Resource Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC228145/
ISSN: 0095-1137
Internal ID Number: 00026
Health Subject: META ANALYSIS
ADOLESCENT
ADULT
AGED
BACTEREMIA - COMPLICATIONS
BACTEREMIA - MORTALITY
CHILD
CHILD - PRESCHOOL
ENDOTOXINS - BLOOD
GRAM NEGATIVE BACTERIAL INFECTIONS - COMPLICATIONS
GRAM NEGATIVE BACTERIAL INFECTIONS - MORTALITY
HUMANS
INFANT
MIDDLE AGED
ODDS RATIO
PROGNOSIS
RISK FACTORS
SEPSIS - COMPLICATIONS
SEPSIS - MORTALITY
TOXEMIA - COMPLICATIONS
TOXEMIA - MORTALITY
ENDOTOXINS
Type: Journal Article
Article
Appears in Collections:Research Output

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