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http://hdl.handle.net/11054/39
Title: | Reappraisal with meta-analysis of bacteremia, endotoxemia, and mortality in gram-negative sepsis. |
Authors: | Hurley, James C. |
Issue Date: | 1995 |
Publisher: | American Society for Microbiology. |
Place of publication: | Washington |
Publication Title: | Journal of Clinical Microbiology |
Volume: | 33 |
Issue: | 5 |
Start Page: | 1278 |
End Page: | 1282 |
Abstract: | Among patients with suspected sepsis, endotoxemia is variably present in association with gram-negative bacteremia. A total of 738 patients with suspected sepsis from 11 studies could be classified into four groups: 131 (18%) patients had both endotoxemia and gram-negative bacteremia (group 1), 87 (12%) had only gram-negative bacteremia (group 2), and 143 (19%) had only endotoxemia (group 3); in 377 (51%) patients neither could be detected (group 4). By the statistical techniques of meta-analysis, the fatality risk for patients with either endotoxemia or gram-negative bacteremia or both was estimated with group-specific case fatality rates from these studies and expressed as an odds ratio (OR; 95% confidence interval [95% CI]) versus patients with these factors absent. This risk was increased marginally when endotoxemia was detected without gram-negative bacteremia (OR, 2.3; 95% CI, 1.3 to 4.0) or the converse (OR, 2.0; 95% CI, 1.0 to 3.8), in contrast to the striking increase when both endotoxemia and gram-negative bacteremia were detected (OR, 6.3; 95% CI, 4.0 to 10.0). Alone, neither endotoxemia nor gram-negative bacteremia is a strong predictor of outcome in patients with suspected sepsis. However, in combination, the two identify a subpopulation with a substantially increased risk of mortality. |
URI: | http://hdl.handle.net/11054/39 |
Resource Link: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC228145/ |
ISSN: | 0095-1137 |
Internal ID Number: | 00026 |
Health Subject: | META ANALYSIS ADOLESCENT ADULT AGED BACTEREMIA - COMPLICATIONS BACTEREMIA - MORTALITY CHILD CHILD - PRESCHOOL ENDOTOXINS - BLOOD GRAM NEGATIVE BACTERIAL INFECTIONS - COMPLICATIONS GRAM NEGATIVE BACTERIAL INFECTIONS - MORTALITY HUMANS INFANT MIDDLE AGED ODDS RATIO PROGNOSIS RISK FACTORS SEPSIS - COMPLICATIONS SEPSIS - MORTALITY TOXEMIA - COMPLICATIONS TOXEMIA - MORTALITY ENDOTOXINS |
Type: | Journal Article Article |
Appears in Collections: | Research Output |
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