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http://hdl.handle.net/11054/36
Title: | Concordance of endotoxemia with gram-negative bacteremia: a meta-analysis using receiver operating characteristic curves. |
Authors: | Hurley, James C. |
Issue Date: | 2000 |
Publisher: | American Medical Association |
Place of publication: | Chicago |
Publication Title: | Archives of Pathology & Laboratory Medicine |
Volume: | 124 |
Issue: | 8 |
Start Page: | 1157 |
End Page: | 1164 |
Abstract: | OBJECTIVE: To apply meta-analysis to compare the concordance between the results of 2 types of limulus amebocyte lysate (LAL) assay, gelation (GLAL) and chromogenic (CLAL), with the detection of gram-negative bacteremia in patients with suspected bacteremia. DESIGN: Meta-analysis using receiver operating characteristic-based analytical method. DATA SOURCES: MEDLINE literature search and manual reviews of article bibliographies together with direct approaches to authors of potentially eligible studies. STUDY SELECTION: The studies that were selected had all included at least 10 patients, of whom at least 2 patients were diagnosed with gram-negative bacteremia, and all had data available for extraction into a contingency table format. RESULTS: Fifty-six studies (28 GLAL and 28 CLAL studies) met the inclusion criteria. Studies were stratified by type of test (GLAL vs CLAL). Each analysis was repeated with smaller studies excluded. There was no difference between the 2 types of LAL assays. Among the CLAL studies, there was no difference between studies that did versus those that did not use the sepsis syndrome criteria as a basis for patient inclusion. Among 45 studies for which data on the proportion of non-Enterobacteriaceae were available, there was a trend toward higher concordance as this proportion increased. CONCLUSIONS: The concordance between the LAL test and the detection of gram-negative bacteremia in patients with suspected bacteremia is no higher with the CLAL assay than with the original GLAL version. However, the concordance is higher among studies with a higher proportion of non-Enterobacteriaceae among the gram-negative bacteremia isolates. |
URI: | http://hdl.handle.net/11054/36 |
Resource Link: | http://www.archivesofpathology.org/doi/full/10.1043/0003-9985(2000)124%3C1157:COEGNB%3E2.0.CO;2 http://www.archivesofpathology.org/action/doSearch?searchText=Concordance+of+endotoxemia+with+gram-negative+bacteremia%3A+a+meta-analysis+using+receiver+operating+characteristic+curves |
ISSN: | 0003-9985 |
Internal ID Number: | 00023 |
Health Subject: | META ANALYSIS ENDOTOXEMIA - BLOOD ENDOTOXEMIA - DIAGNOSIS ENDOTOXEMIA - ETIOLOGY ENTEROBACTERIACEAE - ISOLATION AND PURIFICATION ENTEROBACTERIACEAE INFECTIONS - BLOOD ENTEROBACTERIACEAE INFECTIONS - COMPLICATIONS ENTEROBACTERIACEAE INFECTIONS - DIAGNOSIS ENTEROBACTERIACEAE INFECTIONS - MICROBIOLOGY EVALUATION STUDIES AS TOPIC GRAM NEGATIVE BACTERIAL INFECTIONS - BLOOD GRAM NEGATIVE BACTERIAL INFECTIONS - COMPLICATIONS GRAM NEGATIVE BACTERIAL INFECTIONS - DIAGNOSIS GRAM NEGATIVE BACTERIAL INFECTIONS - MICROBIOLOGY HUMANS LIMULUS TEST LOGISTIC MODELS PREDICTIVE VALUE OF TESTS ROC CURVE REPRODUCIBILITY OF RESULTS |
Type: | Journal Article Article |
Appears in Collections: | Research Output |
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