1. Grampians Health Archive & Research Repository
  2. Grampians Health Archive & Research Repository
  3. Research Output
Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/2885
Full metadata record
DC FieldValueLanguage
dc.contributorSohail, Asmaen_US
dc.contributorZhong, S.en_US
dc.contributorNguyen, P.en_US
dc.contributorMcGuiness, S.en_US
dc.contributorLeder, K.en_US
dc.date.accessioned2025-01-13T02:36:19Z-
dc.date.available2025-01-13T02:36:19Z-
dc.date.issued2024-
dc.identifier.govdoc02889en_US
dc.identifier.urihttp://hdl.handle.net/11054/2885-
dc.descriptionObjectives: Given the complex role of immunity in dengue severity, we aimed to review the clinical course of dengue infection in immunocompromised patients. Methods: We conducted a systematic review of studies reporting outcomes among immunocompromised patients with laboratory-confirmed dengue infection. Meta-analysis using the Mantel-Haenszel method (fixed effects) was performed for studies with control groups. We registered the study with PROSPERO (No. CRD42021258930). Results: We included 115 studies. Among these, 30 studies compared immunocompromised (cases) and nonimmunocompromised (control) patients, focusing mainly on children (n = 22 studies) with malnutrition (n=18). Immunocompromised patients had a higher likelihood of dengue complications (OR 1.87; 95% CI: 1.04-3.35]) but a lower likelihood of severe dengue (OR 0.83; 95% CI: 0.69-1.00]. No significant difference in mortality was observed. In the 85 studies focused solely on immunocompromised patients, severe dengue and mortality rates were 9% and 4%, respectively, mostly among adult solid organ transplant recipients and those with inflammatory diseases. Immunosuppressive treatment alterations and temporary graft dysfunction were reported. Conclusion: Immunocompromised patients have an increased risk of dengue-related complications. However, definitive conclusions about the comparative severity of dengue across different immunocompromised patient groups are limited by a lack of robust data, highlighting the need for well-designed future studies.en_US
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2024-12-24T00:03:29Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2025-01-13T02:36:19Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2025-01-13T02:36:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2024en
dc.titleDengue fever in immunocompromised patients: A systematic review and meta-analysis.en_US
dc.typeJournal Articleen_US
dc.type.specifiedArticleen_US
dc.bibliographicCitation.titleInternational Journal of Infectious Diseasesen_US
dc.bibliographicCitation.volume149en_US
dc.bibliographicCitation.stpage107272en_US
dc.subject.healththesaurusIMMUNOSUPPRESIONen_US
dc.subject.healththesaurusIMMUNOSUPPRESSED HOSTen_US
dc.subject.healththesaurusCLINICAL OUTCOMESen_US
dc.subject.healththesaurusMETA-ANALYSISen_US
dc.subject.healththesaurusVECTOR BORNE DISEASEen_US
dc.subject.healththesaurusARBOVIRAL DISEASEen_US
dc.subject.healththesaurusARBOVIRUSen_US
dc.subject.healththesaurusTROPICAL INFECTIONSen_US
dc.subject.healththesaurusIMPORTED INFECTIONSen_US
dc.subject.healththesaurusINFECTIOUS DISEASEen_US
dc.identifier.doihttps://doi.org/10.1016/j.ijid.2024.107272en_US
Appears in Collections:Research Output

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.