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Title: Transfusion practice and guidelines in Australian and New Zealand intensive care units.
Authors: Westbrook, A.
Pettila, V.
Nichol, A.
Bailey, M. J.
Syres, G.
Murray, L.
Bellomo, R.
Wood, E.
Phillips, L. E.
Street, A.
French, C.
Orford, N.
Santamaria, J.
Cooper, D. J.
Institutional Author: ANZICS Clinical Trials Group
Issue Date: 2010
Publisher: Springer Verlag
Place of publication: Germany
Publication Title: Intensive Care Medicine
Volume: 36
Issue: 7
Start Page: 1138
End Page: 1146
Abstract: Objective To describe the relationship between clinical practice and national guidelines for the transfusion of red blood cells (RBCs), fresh frozen plasma (FFP), platelets, and cryoprecipitate in Australian and New Zealand intensive care units (ICUs). Setting Forty-seven ICUs over a 5-week period from August to September 2008. Design Prospective, observational, multicentre, cohort study. Patients A total of 874 patients receiving any type of blood transfusion. Methods All patients who were transfused at least one unit of any blood component were included. Patient-specific and blood-component specific data were gathered. Pre-transfusion haemoglobin, platelet count, international normalised ratio (INR), and fibrinogen levels were compared to national guidelines. Results Of all 874 patients, 757 received RBCs (86.6%), 231 (26.4%) received platelets, 340 (38.9%) received FFP, and 78 (8.9%) received cryoprecipitate. Bleeding was the reason for administration of RBCs in 46%, FFP in 55%, and platelets in 47% of transfusions. The mean (SD) pre-transfusion haemoglobin was 77.6 (9.5) g/l, while the geometric means (95% CI) for platelet count, INR, and fibrinogen were 67.0 (59.7–75.3) × 109/l, 1.84 (1.76–1.93), and 1.4 (1.1–1.8) g/l, respectively. The proportions of transfusions not adherent to guidelines were 2% for RBC, but 53% for platelets, 29% for FFP, and 88% for cryoprecipitate (RBC vs. other transfusion p < 0.001 for all). Conclusions Transfusion practice of RBCs in Australian and New Zealand ICUs is restrictive and is concordant with guidelines. However, the transfusion of other blood components is not. This study was conducted with data obtained from Ballarat Health Services - R. Gazzard; C. Tauschke; D. Hill.
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ISSN: 0342-4642
Internal ID Number: 00267
Health Subject: ICU
Type: Journal Article
Appears in Collections:Research Output

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