Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/265
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLucas, R. M.en
dc.contributor.authorPonsonby, A. L.en
dc.contributor.authorDear, K.en
dc.contributor.authorValery, P. C.en
dc.contributor.authorPender, M. P.en
dc.contributor.authorTaylor, B. V.en
dc.contributor.authorKilpatrick, T. J.en
dc.contributor.authorDwyer, T.en
dc.contributor.authorCoulthard, A.en
dc.contributor.authorChapman, C.en
dc.contributor.authorvan der Mei, I.en
dc.contributor.authorWilliams, D.en
dc.contributor.authorMcMichael, A. J.en
dc.date.accessioned2013-05-28T05:28:31Zen
dc.date.available2013-05-28T05:28:31Zen
dc.date.issued2011en
dc.identifier.govdoc00254en
dc.identifier.issn0028-3878en
dc.identifier.urihttp://hdl.handle.net/11054/265en
dc.description.abstractObjectives: To examine whether past and recent sun exposure and vitamin D status (serum 25-hydroxyvitamin D [25(OH)D] levels) are associated with risk of first demyelinating events (FDEs) and to evaluate the contribution of these factors to the latitudinal gradient in FDE incidence in Australia. This case study was undertaken with assistance from the BHS. Methods: This was a multicenter incident case-control study. Cases (n = 216) were aged 18–59 years with a FDE and resident within one of 4 Australian centers (from latitudes 27°S to 43°S), from November 1, 2003, to December 31, 2006. Controls (n = 395) were matched to cases on age, sex, and study region, without CNS demyelination. Exposures measured included self-reported sun exposure by life stage, objective measures of skin phenotype and actinic damage, and vitamin D status. Results: Higher levels of past, recent, and accumulated leisure-time sun exposure were each associated with reduced risk of FDE, e.g., accumulated leisure-time sun exposure (age 6 years to current), adjusted odds ratio (AOR) = 0.70 (95% confidence interval [CI] 0.53–0.94) for each ultraviolet (UV) dose increment of 1,000 kJ/m2 (range 508–6,397 kJ/m2). Higher actinic skin damage (AOR = 0.39 [95% CI 0.17–0.92], highest grade vs the lowest) and higher serum vitamin D status (AOR = 0.93 [95% CI 0.86–1.00] per 10 nmol/L increase in 25(OH)D) were independently associated with decreased FDE risk. Differences in leisure-time sun exposure, serum 25(OH)D level, and skin type additively accounted for a 32.4% increase in FDE incidence from the low to high latitude regions. Conclusions: Sun exposure and vitamin D status may have independent roles in the risk of CNS demyelination. Both will need to be evaluated in clinical trials for multiple sclerosis prevention. Research was undertaken which included referrals to the study from Ballarat Health Services physician David McKnight.en
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2013-05-22T02:16:46Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2013-05-28T05:28:31Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2013-05-28T05:28:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2011en
dc.publisherAmerican Acadamy of of Neurologyen
dc.relation.urihttp://www.neurology.org/content/76/6/540.abstracten
dc.titleSun exposure and vitamin D are independent risk factors for CNS demyelination.en
dc.typeJournal Articleen
dc.type.specifiedArticleen
dc.bibliographicCitation.titleNeurologyen
dc.bibliographicCitation.volume76en
dc.bibliographicCitation.issue6en
dc.bibliographicCitation.stpage540en
dc.bibliographicCitation.endpage548en
dc.publisher.placePhilladelphia, PAen
dc.subject.healththesaurusSUN EXPOSUREen
dc.subject.healththesaurusVITAMIN DEFICIENCYen
dc.subject.healththesaurusHYDROXYVITAMIN Den
dc.subject.healththesaurusCASE STUDYen
dc.subject.healththesaurusMULTIPLE SCLEROSISen
dc.subject.healththesaurusCENTRAL NERVOUS SYSTEMen
dc.subject.healththesaurusDEMYELINATIONen
dc.date.issuedbrowse2011-01-01en
Appears in Collections:Research Output

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.