Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/22
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dc.contributor.authorHurley, James C.en
dc.date.accessioned2012-10-02T02:00:51Zen
dc.date.available2012-10-02T02:00:51Zen
dc.date.issued1993en
dc.identifier.govdoc00009en
dc.identifier.issn0140-6736en
dc.identifier.urihttp://hdl.handle.net/11054/22en
dc.description.abstractThere is strong evidence to implicate endotoxin released from gram negative bacteria in the pathogenesis of the sepsis syndrome and related conditions, but equally compelling data bring the role of endotoxin into doubt. Reappraisal of endotoxin and its release from gram negative bacteria suggests that it is not directly responsible for the complications of sepsis syndrome. Rather, release of endotoxin is a marker for the transition of gram negative organisms to cell-wall-deficient forms (L-forms) that may persist undetected despite antibiotic therapy directed against the parental form. This transition has two consequences in compromised patients: L-forms cause organ failure, and they serve as a sanctuary from which cell-wall-intact revertants may arise.en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2012-10-02T02:00:51Z (GMT) No. of bitstreams: 0en
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2012-10-02T01:38:53ZNo. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2012-10-02T02:00:51Z (GMT). No. of bitstreams: 0 Previous issue date: 1993en
dc.publisherElseiver Limiteden
dc.titleReappraisal of the role of endotoxin in the sepsis syndrome.en
dc.typeJournal Articleen
dc.type.specifiedArticleen
dc.bibliographicCitation.titleThe Lanceten
dc.bibliographicCitation.volume341en
dc.bibliographicCitation.issue8853en
dc.bibliographicCitation.stpage1133en
dc.bibliographicCitation.endpage1135en
dc.publisher.placeLondonen
dc.subject.healththesaurusRESPIRATORY SYSTEMen
dc.subject.healththesaurusMEDICAL DISORDERSen
dc.subject.healththesaurusBACTERIAen
dc.subject.healththesaurusGRAM NEGATIVE BACTERIAen
dc.subject.healththesaurusDRUG THERAPYen
dc.subject.healththesaurusHUMANSen
dc.subject.healththesaurusPHYSIOLOGYen
dc.subject.healththesaurusENDOTOXINSen
dc.subject.healththesaurusGRAM NEGATIVE BACTERIAL INFECTIONSen
dc.date.issuedbrowse1993-01-01en
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