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http://hdl.handle.net/11054/1845
Title: | Sunitinib-induced adrenal crisis in a patient with pre-existing immunotherapy-related hypopituitarism. |
Author: | Javaid, Aanadil Mathai, Jared Song, David Brown, Stephen |
Issue Date: | 2022 |
Publication Title: | Case Reports in Oncology |
Volume: | 15 |
Start Page: | 1 |
End Page: | 6 |
Abstract: | Sunitinib is a tyrosine kinase inhibitor that is frequently used in the treatment of metastatic renal cell carcinoma (mRCC). As a multikinase inhibitor, numerous off-target side effects of this medication are widely recognized. More recently, endocrine side effects, including hypoadrenalism, are becoming more apparent. We report a case in which a 71-year-old female experienced recurrent adrenal crises when managed with sunitinib for mRCC on a background of immune-related hypopituitarism and hypoadrenalism as a result of previous treatment with immunotherapy. Clinicians should be aware of this potential toxicity when using such medications and consider further investigation in the appropriate clinical setting. |
URI: | http://hdl.handle.net/11054/1845 |
DOI: | https://doi.org/10.1159/000521206 |
Internal ID Number: | 01864 |
Health Subject: | SUNITINIB HYPOADRENALISM ADRENAL CRISIS IMMUNOTHERAPY SIDE EFFECTS |
Type: | Journal Article Article |
Appears in Collections: | Research Output |
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