Please use this identifier to cite or link to this item:
http://hdl.handle.net/11054/1831
Title: | Selective digestive decontamination, a seemingly effective regimen with individual benefit or a flawed concept with population harm? |
Author: | Hurley, James C. |
Issue Date: | 2021 |
Publication Title: | Critical Care |
Volume: | 25 |
Issue: | 1 |
Start Page: | 323 |
Abstract: | Selective digestive decontamination (SDD) regimens, variously constituted with topical antibiotic prophylaxis (TAP) and protocolized parenteral antibiotic prophylaxis (PPAP), appear highly effective for preventing ICU-acquired infections but only within randomized concurrent control trials (RCCT’s). Confusingly, SDD is also a concept which, if true, implies population benefit. The SDD concept can finally be reified in humans using the broad accumulated evidence base, including studies of TAP and PPAP that used non-concurrent controls (NCC), as a natural experiment. However, this test implicates overall population harm with higher event rates associated with SDD use within the ICU context. |
URI: | http://hdl.handle.net/11054/1831 |
DOI: | https://doi.org/10.1186/s13054-021-03744-w |
Internal ID Number: | 01785 |
Health Subject: | BACTEREMIA MECHANICAL VENTILATION SELECTIVE DIGESTIVE DECONTAMINATION POLYMYXIN |
Type: | Journal Article Article |
Appears in Collections: | Research Output |
Files in This Item:
File | Description | Size | Format | |
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Obtained from Critical Care.pdf | Obtained from Critical Care | 1.8 MB | Adobe PDF | ![]() View/Open |
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