Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/1831
Title: Selective digestive decontamination, a seemingly effective regimen with individual benefit or a flawed concept with population harm?
Author: Hurley, James C.
Issue Date: 2021
Publication Title: Critical Care
Volume: 25
Issue: 1
Start Page: 323
Abstract: Selective digestive decontamination (SDD) regimens, variously constituted with topical antibiotic prophylaxis (TAP) and protocolized parenteral antibiotic prophylaxis (PPAP), appear highly effective for preventing ICU-acquired infections but only within randomized concurrent control trials (RCCT’s). Confusingly, SDD is also a concept which, if true, implies population benefit. The SDD concept can finally be reified in humans using the broad accumulated evidence base, including studies of TAP and PPAP that used non-concurrent controls (NCC), as a natural experiment. However, this test implicates overall population harm with higher event rates associated with SDD use within the ICU context.
URI: http://hdl.handle.net/11054/1831
DOI: https://doi.org/10.1186/s13054-021-03744-w
Internal ID Number: 01785
Health Subject: BACTEREMIA
MECHANICAL VENTILATION
SELECTIVE DIGESTIVE DECONTAMINATION
POLYMYXIN
Type: Journal Article
Article
Appears in Collections:Research Output

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