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http://hdl.handle.net/11054/1828
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DC Field | Value | Language |
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dc.contributor | Fernando, H. | en_US |
dc.contributor | Duffy, S. | en_US |
dc.contributor | Low, A. | en_US |
dc.contributor | Dinh, D. | en_US |
dc.contributor | Adrianopoulos, N. | en_US |
dc.contributor | Sharma, Anand | en_US |
dc.contributor | Karlheinz, P. | en_US |
dc.contributor | Stub, D. | en_US |
dc.contributor | Leong, Kai'En | en_US |
dc.contributor | Ajani, A. | en_US |
dc.contributor | Clark, D. | en_US |
dc.contributor | Freeman, M. | en_US |
dc.contributor | Sebastian, M. | en_US |
dc.contributor | Brennan, A. | en_US |
dc.contributor | Selkrig, L. | en_US |
dc.contributor | Reid, C. | en_US |
dc.contributor | Kaye, D. | en_US |
dc.contributor | Oqueli, Ernesto | en_US |
dc.date.accessioned | 2021-11-30T23:07:18Z | - |
dc.date.available | 2021-11-30T23:07:18Z | - |
dc.date.issued | 2021 | - |
dc.identifier.govdoc | 01788 | en_US |
dc.identifier.uri | http://hdl.handle.net/11054/1828 | - |
dc.description.abstract | The short- and long-term implications of identifying totally occluded culprit coronary arteries (TOCCA) in patients presenting with non-ST-elevation myocardial infarction (NSTEMI) have not been well studied. This study compares clinical characteristics, short- and long-term outcomes of patients with NSTEMI identified with TOCCA to that of patients with non-TOCCA undergoing percutaneous coronary intervention (PCI). We analyzed data from patients with NSTEMI undergoing single-vessel PCI within the Melbourne Interventional Group multi-center registry between 2005 and 2017. Those with TOCCA were compared to those with non-TOCCA. The primary endpoint was 30-day major adverse cardiac events (MACE). Secondary endpoints included 12-month MACE and long-term mortality. A total of 6,829 patients with NSTEMI had single-vessel PCI of which 954 (14%) had TOCCA. Most TOCCA were non-left anterior descending (right coronary artery 39% versus circumflex 33% versus left anterior descending 26%; p <0.001). Cardiogenic shock and left ventricular dysfunction were higher in the TOCCA group, but non-TOCCA patients had more baseline comorbidities. Thirty-day MACE was higher in the TOCCA group (6.7% versus 3.8%; p <0.001). Long-term mortality with an average follow-up of 4.9 years was higher in the non-TOCCA group (12% versus 18%, p <0.01). Multivariable Cox-proportional hazards regression identified TOCCA as an independent predictor of 30-day MACE (HR = 1.93; 95%CI: 1.4-2.6), but not long-term mortality, which was predicted by baseline comorbidities. In conclusion, while patients with NSTEMI with TOCCA undergoing PCI represent a more unstable subgroup early on, long-term outcomes appear more dependent on baseline comorbidities. | en_US |
dc.description.provenance | Submitted by Gemma Siemensma (gemmas@bhs.org.au) on 2021-11-22T05:21:38Z No. of bitstreams: 0 | en |
dc.description.provenance | Approved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2021-11-30T23:07:18Z (GMT) No. of bitstreams: 0 | en |
dc.description.provenance | Made available in DSpace on 2021-11-30T23:07:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2021 | en |
dc.title | Totally occluded culprit coronary artery in patients with non-ST-elevation myocardial infarction undergoing percutaneous coronary intervention. | en_US |
dc.type | Journal Article | en_US |
dc.type.specified | Article | en_US |
dc.bibliographicCitation.title | The American Journal of Cardiology | en_US |
dc.bibliographicCitation.volume | 56 | en_US |
dc.bibliographicCitation.stpage | 52 | en_US |
dc.bibliographicCitation.endpage | 57 | en_US |
dc.subject.healththesaurus | PCI | en_US |
dc.subject.healththesaurus | PERCUTANEOUS CORONARY INTERVENTION | en_US |
dc.subject.healththesaurus | STEMI | en_US |
dc.subject.healththesaurus | MYOCARDIAL INFARCTION | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.amjcard.2021.06.043 | en_US |
Appears in Collections: | Research Output |
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