TTF1 expression in advanced lung adenocarcinoma and survival outcome: an observational study.

Abstract

Prognosis of advanced lung adenocarcinoma remains poor despite significant advances in treatment options. Current literature calls for independent prognostic biomarkers to better stratify patient risk. Thyroid transcription factor 1 (TTF1) is regulatory protein that is suggested to be a favourable prognostic indicator independent of stage at diagnosis. The mechanism for this remains unclear with loss of differentiation of tumour a possible explanation. Further research, however, is needed for clinical application. This study explores TTF1 expression in adenocarcinoma of the lung and its correlation to survival outcomes as well as explores patterns of incidence in relation to tumour grade, gain of function mutations and PD-L1 status.