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dc.contributorTan, M.en_US
dc.contributorDinh, D.en_US
dc.contributorGayed, D.en_US
dc.contributorLiang, D.en_US
dc.contributorBrennan, A.en_US
dc.contributorDuffy, S.en_US
dc.contributorClark, D.en_US
dc.contributorAjani, A.en_US
dc.contributorOqueli, Ernestoen_US
dc.contributorRoberts, L.en_US
dc.contributorReid, C.en_US
dc.contributorFreeman, M.en_US
dc.contributorChandrasekhar, J.en_US
dc.description.abstractIntroduction: The dual antiplatelet (DAPT) score was developed to identify patients more likely to derive benefit (score ≥2) or harm (score <2) from DAPT beyond 1-year post PCI. We sought to examine long-term mortality after PCI by the DAPT score in patients treated with DAPT per local guidelines. Methods: We examined data from the MIG PCI database from 2005 to 2018 in whom the DAPT score could be derived and grouped them as score ≥2 or <2. Long-term mortality was assessed from National Death Index linkage. The primary endpoint was long-term mortality examined using survival analysis. Secondary endpoints included 30-day ischaemic outcomes and in-hospital major bleeding. Results: Out of 27,740 patients in the study, 9,401 (33.9%) had DAPT score ≥2. They were younger and included more females and higher prevalence of renal impairment. DAPT score ≥2 patients had higher in-hospital major bleeding, 30-day mortality, MI and target vessel revascularisation. DAPT score ≥2 patients had lower long-term survival to 12 years (p<0.001 for all). Conclusion: A third of all-comer PCI patients had DAPT score ≥2 with greater short-term risk of ischaemic and bleeding outcomes, as well as long-term mortality. Theoretically, those with DAPT score ≥2 would benefit from longer duration of DAPT as ischaemic risk outweighs bleeding risk. However, given our finding of increased short-term bleeding risk and long-term mortality, dynamic bleeding risk assessment should be undertaken to guide pharmacotherapy strategies.en_US
dc.description.provenanceSubmitted by Gemma Siemensma ( on 2021-08-31T04:07:32Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma ( on 2021-10-07T03:22:05Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2021-10-07T03:22:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2021en
dc.titleAssociations between DAPT score and long-term mortality post PCI.en_US
dc.bibliographicCitation.conferencedateAugust 4-7en_US
dc.bibliographicCitation.conferencename69th CSANZ Annual Scientific Meeting 43rd Annual Scientific Meeting of the International Society for Heart Research ANZET 21en_US
dc.subject.healththesaurusDUAL ANTIPLATELETen_US
Appears in Collections:Research Output

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