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http://hdl.handle.net/11054/1793
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DC Field | Value | Language |
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dc.contributor | Tan, M. | en_US |
dc.contributor | Dinh, D. | en_US |
dc.contributor | Gayed, D. | en_US |
dc.contributor | Liang, D. | en_US |
dc.contributor | Brennan, A. | en_US |
dc.contributor | Duffy, S. | en_US |
dc.contributor | Clark, D. | en_US |
dc.contributor | Ajani, A. | en_US |
dc.contributor | Oqueli, Ernesto | en_US |
dc.contributor | Roberts, L. | en_US |
dc.contributor | Reid, C. | en_US |
dc.contributor | Freeman, M. | en_US |
dc.contributor | Chandrasekhar, J. | en_US |
dc.date.accessioned | 2021-10-07T03:22:05Z | - |
dc.date.available | 2021-10-07T03:22:05Z | - |
dc.date.issued | 2021 | - |
dc.identifier.govdoc | 01756 | en_US |
dc.identifier.uri | http://hdl.handle.net/11054/1793 | - |
dc.description.abstract | Introduction: The dual antiplatelet (DAPT) score was developed to identify patients more likely to derive benefit (score ≥2) or harm (score <2) from DAPT beyond 1-year post PCI. We sought to examine long-term mortality after PCI by the DAPT score in patients treated with DAPT per local guidelines. Methods: We examined data from the MIG PCI database from 2005 to 2018 in whom the DAPT score could be derived and grouped them as score ≥2 or <2. Long-term mortality was assessed from National Death Index linkage. The primary endpoint was long-term mortality examined using survival analysis. Secondary endpoints included 30-day ischaemic outcomes and in-hospital major bleeding. Results: Out of 27,740 patients in the study, 9,401 (33.9%) had DAPT score ≥2. They were younger and included more females and higher prevalence of renal impairment. DAPT score ≥2 patients had higher in-hospital major bleeding, 30-day mortality, MI and target vessel revascularisation. DAPT score ≥2 patients had lower long-term survival to 12 years (p<0.001 for all). Conclusion: A third of all-comer PCI patients had DAPT score ≥2 with greater short-term risk of ischaemic and bleeding outcomes, as well as long-term mortality. Theoretically, those with DAPT score ≥2 would benefit from longer duration of DAPT as ischaemic risk outweighs bleeding risk. However, given our finding of increased short-term bleeding risk and long-term mortality, dynamic bleeding risk assessment should be undertaken to guide pharmacotherapy strategies. | en_US |
dc.description.provenance | Submitted by Gemma Siemensma (gemmas@bhs.org.au) on 2021-08-31T04:07:32Z No. of bitstreams: 0 | en |
dc.description.provenance | Approved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2021-10-07T03:22:05Z (GMT) No. of bitstreams: 0 | en |
dc.description.provenance | Made available in DSpace on 2021-10-07T03:22:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2021 | en |
dc.title | Associations between DAPT score and long-term mortality post PCI. | en_US |
dc.type | Conference | en_US |
dc.type.specified | Paper | en_US |
dc.bibliographicCitation.conferencedate | August 4-7 | en_US |
dc.bibliographicCitation.conferencename | 69th CSANZ Annual Scientific Meeting 43rd Annual Scientific Meeting of the International Society for Heart Research ANZET 21 | en_US |
dc.bibliographicCitation.conferenceplace | Online | en_US |
dc.subject.healththesaurus | DUAL ANTIPLATELET | en_US |
dc.subject.healththesaurus | CARDIOLOGY | en_US |
dc.subject.healththesaurus | PCI | en_US |
dc.subject.healththesaurus | PERCUTANEOS CORONARY INTERVENTION | en_US |
Appears in Collections: | Research Output |
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