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dc.contributorHurley, James C.en_US
dc.description.abstractAbstract There are several antiseptic, antibiotic and non-decontamination-based interventions for preventing intensive care unit (ICU) acquired infection. These have been evaluated in >200 studies. Infection prevention using topical antibiotic prophylaxis (TAP) appears to be the most effective. Whether antibiotic use in the ICU may influence the risk of infection among concurrent control patients within the same ICU and result in asymmetrical herd effects cannot be resolved with individual studies examined in isolation. The collective observations within control and intervention groups from numerous ICU infection prevention studies simulates a multi-center natural experiment enabling the herd effects of antibiotics to be evaluated. Among the TAP control groups, the incidences for both ventilator associated pneumonia (VAP) and mortality are unusually high in comparison to literature-derived benchmarks. Paradoxically, amongst the TAP intervention groups, the incidences of mortality are also unusually high and the VAP incidences are similar (i.e., not lower) compared to the incidences among studies of other interventions. By contrast, the mortality incidences among the intervention groups of other studies are similar to those among the intervention groups of TAP studies. Using topical antibiotics to prevent infections acquired within the ICU environment may result in profoundly asymmetrical effects. View Full-Texten_US
dc.description.provenanceSubmitted by Gemma Siemensma ( on 2021-08-20T01:49:45Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma ( on 2021-10-04T03:41:52Z (GMT) No. of bitstreams: 1 symmetry-13-01027-v2.pdf: 1032705 bytes, checksum: ddbb5e053086e9ca6d57cea9e0793433 (MD5)en
dc.description.provenanceMade available in DSpace on 2021-10-04T03:41:52Z (GMT). No. of bitstreams: 1 symmetry-13-01027-v2.pdf: 1032705 bytes, checksum: ddbb5e053086e9ca6d57cea9e0793433 (MD5) Previous issue date: 2021en
dc.titleAsymmetric effects of decontamination using topical antibiotics for the ICU patient.en_US
dc.typeJournal Articleen_US
dc.subject.healththesaurusTOPICAL ANTIBIOTIC PROPHYLAXISen_US
dc.subject.healththesaurusSTUDY DESIGNen_US
dc.subject.healththesaurusINTENSIVE CAREen_US
dc.subject.healththesaurusMECHANICAL VENTILATIONen_US
dc.subject.healththesaurusHERD EFFECTSen_US
dc.subject.healththesaurusVENTILATOR ASSOCIATED PNEUMONIAen_US
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