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http://hdl.handle.net/11054/1726
Title: | Standard-dose osimertinib in EGFR-mutated non-small-cell lung adenocarcinoma with leptomeningeal disease. |
Author: | McLean, L. S. Faisal, Wasek Parakh, S. Kao, S. C. Lewis, C. R. Chin, M. T. Vosokoboynick, M. Itchins, M. J. Jennens, R. R. Broad, A. R. Morris, T. A. Solomon, B. J. |
Issue Date: | 2021 |
Publication Title: | JCO Precision Oncology |
Volume: | 5 |
Start Page: | 561 |
End Page: | 568 |
Abstract: | PURPOSE Leptomeningeal disease (LMD) in epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma is associated with a poor prognosis and limited treatment options. Osimertinib is a potent third-generation EGFR tyrosine kinase inhibitor with confirmed CNS penetration. This study reports on outcomes of patients with EGFR-mutated non–small-cell lung cancer who developed LMD and were subsequently treated with osimertinib. METHODS We identified patients treated with osimertinib 80 mg PO daily under a compassionate access scheme across nine tertiary Australian institutes between July 2017 and July 2020. Patient demographics, tumor characteristics, and treatment history were collected. Median overall survival, median progression-free survival, disease control rates (DCR), and overall response rates (ORR) were assessed. Kaplan-Meier analysis was performed and descriptive statistics were used. RESULTS Thirty-nine patients were analyzed of which 74% were female. Exon 19 deletions (49%) and L858R point mutations (41%) were the most common EGFR mutations. Forty-nine percentage of patients were Eastern Cooperative Oncology Group 1. The median duration of osimertinib therapy was 6 months. The extracranial DCR and ORR were 60% and 54%, and the intracranial DCR and ORR were 68% and 53%, respectively. Median overall survival was 10.5 months (95% CI, 8.17 to 15.05 months). CONCLUSION There are limited treatment options for LMD in EGFR-positive lung cancer, and osimertinib at a dose of 80 mg daily is an active therapeutic option for these patients. |
URI: | http://hdl.handle.net/11054/1726 |
DOI: | https://doi.org/10.1200/PO.20.00464 |
Internal ID Number: | 01712 |
Health Subject: | EPIDERMAL GROWTH FACTOR RECEPTOR LUNG DISEASE LUNG ADENOCARCINOMA LUNG CANCER LEPTOMENINGEAL DISEASE |
Type: | Journal Article Article |
Appears in Collections: | Research Output |
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