Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/1716
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dc.contributorLim, Zheng J.en_US
dc.contributorSubramaniam, A.en_US
dc.contributorReddy, M.en_US
dc.contributorBlecher, G.en_US
dc.contributorKadam, U.en_US
dc.contributorAfroz, A.en_US
dc.contributorBillah, B.en_US
dc.contributorAshwin, S.en_US
dc.contributorKubicki, M.en_US
dc.contributorBilotta, F.en_US
dc.contributorCurtis, J.en_US
dc.contributorRubulotta, F.en_US
dc.date.accessioned2021-01-07T04:08:29Z-
dc.date.available2021-01-07T04:08:29Z-
dc.date.issued2021-
dc.identifier.govdoc01668en_US
dc.identifier.urihttp://hdl.handle.net/11054/1716-
dc.description.abstractRationale: Initial reports of case fatality rates (CFRs) among adults with coronavirus disease (COVID-19) receiving invasive mechanical ventilation (IMV) are highly variable.Objectives: To examine the CFR of patients with COVID-19 receiving IMV.Methods: Two authors independently searched PubMed, Embase, medRxiv, bioRxiv, the COVID-19 living systematic review, and national registry databases. The primary outcome was the "reported CFR" for patients with confirmed COVID-19 requiring IMV. "Definitive hospital CFR" for patients with outcomes at hospital discharge was also investigated. Finally, CFR was analyzed by patient age, geographic region, and study quality on the basis of the Newcastle-Ottawa Scale.Measurements and Results: Sixty-nine studies were included, describing 57,420 adult patients with COVID-19 who received IMV. Overall reported CFR was estimated as 45% (95% confidence interval [CI], 39-52%). Fifty-four of 69 studies stated whether hospital outcomes were available but provided a definitive hospital outcome on only 13,120 (22.8%) of the total IMV patient population. Among studies in which age-stratified CFR was available, pooled CFR estimates ranged from 47.9% (95% CI, 46.4-49.4%) in younger patients (age ≤40 yr) to 84.4% (95% CI, 83.3-85.4%) in older patients (age >80 yr). CFR was also higher in early COVID-19 epicenters. Overall heterogeneity is high (I2 >90%), with nonsignificant Egger's regression test suggesting no publication bias.Conclusions: Almost half of patients with COVID-19 receiving IMV died based on the reported CFR, but variable CFR reporting methods resulted in a wide range of CFRs between studies. The reported CFR was higher in older patients and in early pandemic epicenters, which may be influenced by limited ICU resources. Reporting of definitive outcomes on all patients would facilitate comparisons between studies.Systematic review registered with PROSPERO (CRD42020186997).en_US
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2021-01-07T01:26:59Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2021-01-07T04:08:29Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2021-01-07T04:08:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2021en
dc.titleCase fatality rates for patients with COVID-19 requiring invasive mechanical ventilation. A meta-analysis.en_US
dc.typeJournal Articleen_US
dc.type.specifiedArticleen_US
dc.bibliographicCitation.titleAmerican Journal of Respiratory and Critical Care Medicineen_US
dc.bibliographicCitation.volume203en_US
dc.bibliographicCitation.issue1en_US
dc.bibliographicCitation.stpage54en_US
dc.bibliographicCitation.endpage66en_US
dc.subject.healththesaurusCOVID-19en_US
dc.subject.healththesaurusSARS-CoV-2en_US
dc.subject.healththesaurusCASE FATALITY RATEen_US
dc.subject.healththesaurusINVASIVE MECHANICAL VENTILATIONen_US
dc.subject.healththesaurusMORTALITYen_US
dc.identifier.doihttps://doi.org/10.1164/rccm.202006-2405OCen_US
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