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dc.contributorNoaman, Sameren_US
dc.contributorAndrianopoulos, Nicken_US
dc.contributorBrennan, Angelaen_US
dc.contributorDinh, Diemen_US
dc.contributorReid, Christopheren_US
dc.contributorStub, Dionen_US
dc.contributorBiswas, Sinjinien_US
dc.contributorClark, Daviden_US
dc.contributorShaw, Jamesen_US
dc.contributorAjani, Andrewen_US
dc.contributorFreeman, Melanieen_US
dc.contributorYip, Thomasen_US
dc.contributorOqueli, Ernestoen_US
dc.contributorWalton, Antonyen_US
dc.contributorDuffy, Stephenen_US
dc.contributorChan, Williamen_US
dc.contributoron behalf of the Melbourne Interventional Group Investigatorsen_US
dc.description.abstractObjectives We aimed to assess the outcomes of cardiogenic shock (CS) complicating acute coronary syndromes (ACS). Background CS remains the leading cause of mortality in patients presenting with ACS despite advances in care. Methods We studied 13,184 patients undergoing percutaneous coronary intervention (PCI) for all subtypes of ACS enrolled prospectively in a large multicentre Australian registry (Melbourne Interventional Group registry) from 2005 to 2013. All‐cause mortality was obtained via linkage to the National Death Index. Patients were divided into those with and those without CS. Results Compared to the non‐CS group (n = 12,548, 95.2%), the CS group (n = 636, 4.8%) had a higher proportion of out‐of‐hospital cardiac arrest (OHCA) (31.1 vs. 2.2%) and ST‐elevation myocardial infarction (STEMI) presentation (89 vs. 34%), both p < .01. Patients in the CS group had higher rates of in‐hospital (40.4 vs. 1.2%) and 30‐day (41 vs. 1.7%) mortality compared to the non‐CS group. Long‐term mortality over a median follow‐up of 4.2 years was higher in the CS group (50.6 vs. 13.8%), p < .001. Trends of in‐hospital and 30‐day mortality rates of CS complicating ACS were relatively stable from 2005 to 2013. Predictors of long‐term NDI‐linked mortality within the CS group include severe left ventricular systolic dysfunction (HR 3.0), glomerular filtration rate (GFR) <30 (HR 2.56), GFR 30–59 (HR 1.94), OHCA (HR 1.46), diabetes (HR 1.44), and age (HR 1.02), all p < .05. Conclusions Rates of CS‐related mortality complicating ACS have remained very high and steady over nearly a decade despite progress in STEMI systems of care, PCI techniques, and medical therapy.en_US
dc.description.provenanceSubmitted by Gemma Siemensma ( on 2020-10-12T22:59:38Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma ( on 2020-11-23T06:19:37Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-11-23T06:19:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2020en
dc.titleOutcomes of cardiogenic shock complicating acute coronary syndromes.en_US
dc.typeJournal Articleen_US
dc.bibliographicCitation.titleCatheterization & Cardiovascular Interventionsen_US
dc.subject.healththesaurusACUTE MYOCARDIAL INFARCTION/STEMIen_US
dc.subject.healththesaurusHEART FAILUREen_US
Appears in Collections:Research Output

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