Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/1389
Title: Is selective decontamination (SDD/SOD) safe in the ICU context?
Author: Hurley, James C.
Issue Date: 2019
Publication Title: Journal of Antimicrobial Chemotherapy
Volume: 74
Issue: 5
Start Page: 1167
End Page: 1172
Abstract: Multiple individual studies of selective digestive decontamination/selective oropharyngeal decontamination (SDD/SOD) among ICU patients appear to show potent infection prevention effects. Surprisingly, the event rates for multiple endpoints including ventilator-associated pneumonia, bacteraemia and candidaemia among concurrent control groups within SDD/SOD studies appear unusually high versus other rates in the literature. These paradoxical observations raise concern that the contextual effects of SDD/SOD, as postulated in the original SDD/SOD study, not only exist but also are strong. Until these effects are addressed within an optimally designed study, the safety of SDD/SOD within the ‘whole of ICU’ remains questionable.
URI: http://hdl.handle.net/11054/1389
Resource Link: https://doi.org/10.1093/jac/dky573
Internal ID Number: 01355
Health Subject: SELECTIVE DIGESTIVE DECONTAMINATION
SELECTIVE OROPHARYNGEAL DECONTAMINATION
INFECTION PREVENTION
Type: Journal Article
Article
Appears in Collections:Research Output

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.