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http://hdl.handle.net/11054/1389
Title: | Is selective decontamination (SDD/SOD) safe in the ICU context? |
Author: | Hurley, James C. |
Issue Date: | 2019 |
Publication Title: | Journal of Antimicrobial Chemotherapy |
Volume: | 74 |
Issue: | 5 |
Start Page: | 1167 |
End Page: | 1172 |
Abstract: | Multiple individual studies of selective digestive decontamination/selective oropharyngeal decontamination (SDD/SOD) among ICU patients appear to show potent infection prevention effects. Surprisingly, the event rates for multiple endpoints including ventilator-associated pneumonia, bacteraemia and candidaemia among concurrent control groups within SDD/SOD studies appear unusually high versus other rates in the literature. These paradoxical observations raise concern that the contextual effects of SDD/SOD, as postulated in the original SDD/SOD study, not only exist but also are strong. Until these effects are addressed within an optimally designed study, the safety of SDD/SOD within the ‘whole of ICU’ remains questionable. |
URI: | http://hdl.handle.net/11054/1389 |
Resource Link: | https://doi.org/10.1093/jac/dky573 |
Internal ID Number: | 01355 |
Health Subject: | SELECTIVE DIGESTIVE DECONTAMINATION SELECTIVE OROPHARYNGEAL DECONTAMINATION INFECTION PREVENTION |
Type: | Journal Article Article |
Appears in Collections: | Research Output |
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