Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/1289
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dc.contributorGlobal Burden of Disease Collaboratorsen_US
dc.date.accessioned2019-02-21T04:05:44Z-
dc.date.available2019-02-21T04:05:44Z-
dc.date.issued2018-
dc.identifier.govdoc01231en_US
dc.identifier.urihttp://hdl.handle.net/11054/1289-
dc.description.abstractBackground The lifetime risk of stroke has been calculated in a limited number of selected populations. We sought to estimate the lifetime risk of stroke at the regional, country, and global level using data from a comprehensive study of the prevalence of major diseases. Methods We used the Global Burden of Disease (GBD) Study 2016 estimates of stroke incidence and the competing risks of death from any cause other than stroke to calculate the cumulative lifetime risks of first stroke, ischemic stroke, or hemorrhagic stroke among adults 25 years of age or older. Estimates of the lifetime risks in the years 1990 and 2016 were compared. Countries were categorized into quintiles of the sociodemographic index (SDI) used in the GBD Study, and the risks were compared across quintiles. Comparisons were made with the use of point estimates and uncertainty intervals representing the 2.5th and 97.5th percentiles around the estimate. Results The estimated global lifetime risk of stroke from the age of 25 years onward was 24.9% (95% uncertainty interval, 23.5 to 26.2); the risk among men was 24.7% (95% uncertainty interval, 23.3 to 26.0), and the risk among women was 25.1% (95% uncertainty interval, 23.7 to 26.5). The risk of ischemic stroke was 18.3%, and the risk of hemorrhagic stroke was 8.2%. In high-SDI, high-middle–SDI, and low-SDI countries, the estimated lifetime risk of stroke was 23.5%, 31.1% (highest risk), and 13.2% (lowest risk), respectively; the 95% uncertainty intervals did not overlap between these categories. The highest estimated lifetime risks of stroke according to GBD region were in East Asia (38.8%), Central Europe (31.7%), and Eastern Europe (31.6%), and the lowest risk was in eastern sub-Saharan Africa (11.8%). The mean global lifetime risk of stroke increased from 22.8% in 1990 to 24.9% in 2016, a relative increase of 8.9% (95% uncertainty interval, 6.2 to 11.5); the competing risk of death from any cause other than stroke was considered in this calculation. Conclusions In 2016, the global lifetime risk of stroke from the age of 25 years onward was approximately 25% among both men and women. There was geographic variation in the lifetime risk of stroke, with the highest risks in East Asia, Central Europe, and Eastern Europe. (Funded by the Bill and Melinda Gates Foundation.) Includes data collected from Ballarat Health Services.en_US
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2019-02-06T22:33:43Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2019-02-21T04:05:44Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2019-02-21T04:05:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2018en
dc.relation.urihttps://www.nejm.org/doi/full/10.1056/NEJMoa1804492en_US
dc.titleGlobal, regional, and country-specific lifetime risks of stroke, 1990 and 2016.en_US
dc.typeJournal Articleen_US
dc.type.specifiedArticleen_US
dc.bibliographicCitation.titleNew England Journal of Medicine.en_US
dc.bibliographicCitation.volume379en_US
dc.bibliographicCitation.issue25en_US
dc.bibliographicCitation.stpage2429en_US
dc.bibliographicCitation.endpage2437en_US
dc.subject.healththesaurusSTROKEen_US
dc.subject.healththesaurusGLOBAL BURDEN OF DISEASEen_US
dc.subject.healththesaurusISCHEMIC STROKEen_US
dc.subject.healththesaurusHEMORRHAGIC STROKEen_US
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