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http://hdl.handle.net/11054/1227
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DC Field | Value | Language |
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dc.contributor | Biswas, Sinjini | en_US |
dc.contributor | Andrianopoulos, Nick | en_US |
dc.contributor | Papapostolou, Stavroula | en_US |
dc.contributor | Noaman, Samer | en_US |
dc.contributor | Duffy, Stephen J. | en_US |
dc.contributor | Lefkovits, Jeffrey | en_US |
dc.contributor | Brennan, Angela | en_US |
dc.contributor | Walton, Antony | en_US |
dc.contributor | Shaw, James A. | en_US |
dc.contributor | Ajani, Andrew | en_US |
dc.contributor | Clark, David J. | en_US |
dc.contributor | Freeman, Melanie | en_US |
dc.contributor | Hiew, Chin | en_US |
dc.contributor | Oqueli, Ernesto | en_US |
dc.contributor | Reid, Christopher M. | en_US |
dc.contributor | Stub, Dion | en_US |
dc.contributor | Chan, William | en_US |
dc.date.accessioned | 2018-10-26T00:39:53Z | - |
dc.date.available | 2018-10-26T00:39:53Z | - |
dc.date.issued | 2018 | - |
dc.identifier.govdoc | 01146 | en_US |
dc.identifier.issn | 0195-668X | en_US |
dc.identifier.uri | http://hdl.handle.net/11054/1227 | - |
dc.description.abstract | Aims: The prognosis of patients undergoing percutaneous coronary intervention (PCI) for different subtypes of acute coronary syndromes (ACS) remains unclear. We compared short- and long-term mortality in patients undergoing PCI for unstable angina (UA), non-ST-elevation myocardial infarction (NSTEMI), and ST-elevation myocardial infarction (STEMI). Methods and results: This was a retrospective cohort study of 13 184 patients (5966 STEMI, 5307 NSTEMI, and 1911 UA) undergoing PCI between 1 January 2005 and 30 November 2013 in a multi-centre registry. Clinical and procedural characteristics, as well as outcomes, were compared by ACS subtype. Long-term all-cause mortality data were obtained via linkage to the National Death Index (NDI). Patients with STEMI compared with NSTEMI and UA were younger (62.9 ± 12.8 vs. 64.7 ± 12.5 vs. 65.5 ± 11.8 years; P < 0.01), had fewer comorbidities including diabetes, heart failure, and previous myocardial infarction (all P < 0.01). Procedural success was similar across all groups (P = 0.54). In-hospital, 30-day and 1-year all-cause mortality increased significantly from UA to NSTEMI to STEMI patients (1-year mortality 2.5% vs. 4.5% vs. 8.7%; P < 0.01). Kaplan–Meier survival estimates showed increased early mortality in the STEMI group (log-rank P < 0.01). However, after approximately 8.2 years, survival was similar across all groups. In a proportional-odds model using flexible parametric survival modelling, ACS subtype was not an independent predictor of NDI-linked mortality [UA: odds ratio (OR) 0.85, 95% CI 0.71–1.02; STEMI: OR 1.01, 95% confidence interval (CI) 0.88–1.16; NSTEMI as reference category]. Conclusion: Despite disparate baseline characteristics and differences in short-term mortality, long-term mortality was similar across the spectrum of ACS treated by PCI and contemporary medical therapy. | en_US |
dc.description.provenance | Submitted by Gemma Siemensma (gemmas@bhs.org.au) on 2018-10-26T00:38:43Z No. of bitstreams: 0 | en |
dc.description.provenance | Approved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2018-10-26T00:39:53Z (GMT) No. of bitstreams: 0 | en |
dc.description.provenance | Made available in DSpace on 2018-10-26T00:39:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2018 | en |
dc.title | Does the subtype of acute coronary syndrome treated by percutaneous coronary intervention predict long-term clinical outcomes? | en_US |
dc.type | Journal Article | en_US |
dc.type.specified | Article | en_US |
dc.bibliographicCitation.title | European Heart Journal - Quality of Care and Clinical Outcomes | en_US |
dc.bibliographicCitation.volume | 4 | en_US |
dc.bibliographicCitation.issue | 4 | en_US |
dc.bibliographicCitation.stpage | 318 | en_US |
dc.bibliographicCitation.endpage | 327 | en_US |
dc.subject.healththesaurus | ACUTE CORONARY SYNDROME | en_US |
dc.subject.healththesaurus | MYOCARDIAL INFARCTION | en_US |
dc.subject.healththesaurus | PERCUTANEOUS CORONARY INTERVENTION | en_US |
dc.subject.healththesaurus | RETROSPECTIVE STUDIES | en_US |
dc.subject.healththesaurus | REGISTRIES | en_US |
dc.subject.healththesaurus | PROGNOSIS | en_US |
dc.identifier.doi | https://doi.org/10.1093/ehjqcco/qcy009 | en_US |
Appears in Collections: | Research Output |
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