Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/1227
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dc.contributorBiswas, Sinjinien_US
dc.contributorAndrianopoulos, Nicken_US
dc.contributorPapapostolou, Stavroulaen_US
dc.contributorNoaman, Sameren_US
dc.contributorDuffy, Stephen J.en_US
dc.contributorLefkovits, Jeffreyen_US
dc.contributorBrennan, Angelaen_US
dc.contributorWalton, Antonyen_US
dc.contributorShaw, James A.en_US
dc.contributorAjani, Andrewen_US
dc.contributorClark, David J.en_US
dc.contributorFreeman, Melanieen_US
dc.contributorHiew, Chinen_US
dc.contributorOqueli, Ernestoen_US
dc.contributorReid, Christopher M.en_US
dc.contributorStub, Dionen_US
dc.contributorChan, Williamen_US
dc.date.accessioned2018-10-26T00:39:53Z-
dc.date.available2018-10-26T00:39:53Z-
dc.date.issued2018-
dc.identifier.govdoc01146en_US
dc.identifier.issn0195-668Xen_US
dc.identifier.urihttp://hdl.handle.net/11054/1227-
dc.description.abstractAims: The prognosis of patients undergoing percutaneous coronary intervention (PCI) for different subtypes of acute coronary syndromes (ACS) remains unclear. We compared short- and long-term mortality in patients undergoing PCI for unstable angina (UA), non-ST-elevation myocardial infarction (NSTEMI), and ST-elevation myocardial infarction (STEMI). Methods and results: This was a retrospective cohort study of 13 184 patients (5966 STEMI, 5307 NSTEMI, and 1911 UA) undergoing PCI between 1 January 2005 and 30 November 2013 in a multi-centre registry. Clinical and procedural characteristics, as well as outcomes, were compared by ACS subtype. Long-term all-cause mortality data were obtained via linkage to the National Death Index (NDI). Patients with STEMI compared with NSTEMI and UA were younger (62.9 ± 12.8 vs. 64.7 ± 12.5 vs. 65.5 ± 11.8 years; P < 0.01), had fewer comorbidities including diabetes, heart failure, and previous myocardial infarction (all P < 0.01). Procedural success was similar across all groups (P = 0.54). In-hospital, 30-day and 1-year all-cause mortality increased significantly from UA to NSTEMI to STEMI patients (1-year mortality 2.5% vs. 4.5% vs. 8.7%; P < 0.01). Kaplan–Meier survival estimates showed increased early mortality in the STEMI group (log-rank P < 0.01). However, after approximately 8.2 years, survival was similar across all groups. In a proportional-odds model using flexible parametric survival modelling, ACS subtype was not an independent predictor of NDI-linked mortality [UA: odds ratio (OR) 0.85, 95% CI 0.71–1.02; STEMI: OR 1.01, 95% confidence interval (CI) 0.88–1.16; NSTEMI as reference category]. Conclusion: Despite disparate baseline characteristics and differences in short-term mortality, long-term mortality was similar across the spectrum of ACS treated by PCI and contemporary medical therapy.en_US
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2018-10-26T00:38:43Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2018-10-26T00:39:53Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2018-10-26T00:39:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2018en
dc.titleDoes the subtype of acute coronary syndrome treated by percutaneous coronary intervention predict long-term clinical outcomes?en_US
dc.typeJournal Articleen_US
dc.type.specifiedArticleen_US
dc.bibliographicCitation.titleEuropean Heart Journal - Quality of Care and Clinical Outcomesen_US
dc.bibliographicCitation.volume4en_US
dc.bibliographicCitation.issue4en_US
dc.bibliographicCitation.stpage318en_US
dc.bibliographicCitation.endpage327en_US
dc.subject.healththesaurusACUTE CORONARY SYNDROMEen_US
dc.subject.healththesaurusMYOCARDIAL INFARCTIONen_US
dc.subject.healththesaurusPERCUTANEOUS CORONARY INTERVENTIONen_US
dc.subject.healththesaurusRETROSPECTIVE STUDIESen_US
dc.subject.healththesaurusREGISTRIESen_US
dc.subject.healththesaurusPROGNOSISen_US
dc.identifier.doihttps://doi.org/10.1093/ehjqcco/qcy009en_US
Appears in Collections:Research Output

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