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dc.contributor.authorAtakuziev, Bakhadir U.*
dc.contributor.authorWright, Christine E.*
dc.contributor.authorGraudins, Andis*
dc.contributor.authorNicholson, Graham M.*
dc.contributor.authorWinkel, Kenneth D.*
dc.description.abstractWe describe the first Steatoda capensis envenomation treated with CSL red-back spider antivenom (RBSAV). The patient, a 51-year-old female, developed acute local pain, swelling, redness, and diaphoresis in association with tender lymphadenopathy and hypertension. These features responded, in a dose-dependent manner, to RBSAV. In vitro studies confirmed that RBSAV could neutralize S. capensis venom at equivalent concentrations required to neutralize red-back spider (Latrodectus hasselti) venom. Similar data were obtained using Mexican Latrodectus mactans antivenom (Aracmyn®). Although S. capensis yielded similar quantities of venom protein as L. hasselti, pooled S. capensis and Steatoda grossa venom was more rapidly toxic to insects than either L. hasselti or Latrodectus tredecimguttatus venom. By contrast, both Latrodectus venoms were more potent than S. capensis venom in contracting rat isolated mesenteric arteries. Size-exclusion and anion-exchange chromatography was used to purify a 130 kDa fraction from S. capensis venom that induced contracture and loss of twitch tension in chick isolated biventer cervicis nerve-muscle preparations in a manner similar to α-latrotoxin. This activity was abolished by pre-incubation with RBSAV. We conclude that 'steatodism' may overlap more closely with latrodectism than previously recognized and that this bite should be managed in the same way as for Australian red-back envenomation.en
dc.description.provenanceSubmitted by Gemma Siemensma ( on 2015-12-03T05:57:52Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma ( on 2016-01-20T02:38:51Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2016-01-20T02:38:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.titleEfficacy of Australian red-back spider (Latrodectus hasselti) antivenom in the treatment of clinical envenomation by the cupboard spider Steatoda capensis (Theridiidae).en
dc.typeJournal Article*
dc.publisher.placePhiladephia, PAen
dc.subject.healththesaurusSPIDER VENOMSen
Appears in Collections:Research Output

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