Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/583
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dc.contributor.authorFroessler, Bernden
dc.contributor.authorCollingwood, Joshuaen
dc.contributor.authorHodyl, Nicolette A.en
dc.contributor.authorDekker, Gustaafen
dc.date.accessioned2014-09-01T06:17:25Zen
dc.date.available2014-09-01T06:17:25Zen
dc.date.issued2014en
dc.identifier.govdoc00547en
dc.identifier.issn1471-2393en
dc.identifier.urihttp://hdl.handle.net/11054/583en
dc.description.abstractBackground: Iron deficiency is a common nutritional deficiency amongst women of childbearing age. Peri-partum iron deficiency anaemia (IDA) is associated with significant maternal, fetal and infant morbidity. Current options for treatment are limited: these include oral iron supplementation, which can be ineffective and poorly tolerated, and red blood cell transfusions, which carry an inherent risk and should be avoided. Ferric carboxymaltose is a new treatment option that may be better tolerated. The study was designed to assess the safety and efficacy of iron deficiency anaemia (IDA) correction with intravenous ferric carboxymaltose in pregnant women with mild, moderate and severe anaemia in the second and third trimester. Methods: Prospective observational study; 65 anaemic pregnant women received ferric carboxymaltose up to 15 mg/kg between 24 and 40 weeks of pregnancy (median 35 weeks gestational age, SD 3.6). Treatment effectiveness was assessed by repeat haemoglobin (Hb) measurements and patient report of well-being in the postpartum period. Safety was assessed by analysis of adverse drug reactions and fetal heart rate monitoring during the infusion. Results: Intravenous ferric carboxymaltose infusion significantly increased Hb values (p < 0.01) above baseline levels in all women. Increased Hb values were observed at 3 and 6 weeks post infusion and up to 8 weeks post-infusion. Ferritin values increased significantly after the infusion. Only 4 women had repeat ferritin values post-partum which remained above baseline levels. Fetal heart rate monitoring did not indicate a drug related negative impact on the fetus. Of the 29 (44.6%) women interviewed, 19 (65.5%) women reported an improvement in their well-being and 9 (31%) felt no different after the infusion. None of the women felt worse. No serious adverse effects were found and minor side effects occurred in 13 (20%) patients. Conclusions: Our prospective data is consistent with existing observational reports of the safe and effective use of ferric carboxymaltose in the treatment of iron deficiency anaemia in pregnancy. Keywords: Pregnancy, Iron deficiency, Peri-partum anaemia, Intravenous ferric carboxymaltose, Red blood cell transfusionen
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2014-06-19T06:54:20Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2014-09-01T06:17:25Z (GMT) No. of bitstreams: 1 Froessler_Intravenous ferric.pdf: 198051 bytes, checksum: 7aea84561ff055b774bc5184a9a03c3f (MD5)en
dc.description.provenanceMade available in DSpace on 2014-09-01T06:17:25Z (GMT). No. of bitstreams: 1 Froessler_Intravenous ferric.pdf: 198051 bytes, checksum: 7aea84561ff055b774bc5184a9a03c3f (MD5) Previous issue date: 2014en
dc.publisherBioMed Central Ltd.en
dc.titleIntravenous ferric carboxymaltose for anaemia in pregnancy.en
dc.typeJournal Articleen
dc.type.specifiedArticleen
dc.bibliographicCitation.titleBMC Pregnancy & Childbirthen
dc.bibliographicCitation.volume14en
dc.bibliographicCitation.stpage115en
dc.subject.healththesaurusPREGNANCYen
dc.subject.healththesaurusIRON DEFICIENCYen
dc.subject.healththesaurusPERI-PARTUM ANAEMIAen
dc.subject.healththesaurusANAEMIAen
dc.subject.healththesaurusRED BLOOD CELL TRANSFUSIONen
dc.subject.healththesaurusINTRAVENOUS FERRIC CARBOXYMALTOSEen
dc.date.issuedbrowse2014-01-01en
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