Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/36
Title: Concordance of endotoxemia with gram-negative bacteremia: a meta-analysis using receiver operating characteristic curves.
Authors: Hurley, James C.
Issue Date: 2000
Publisher: American Medical Association
Place of publication: Chicago
Journal title: Archives of Pathology & Laboratory Medicine
Volume: 124
Issue: 8
Start Page: 1157
End Page: 1164
Abstract: OBJECTIVE: To apply meta-analysis to compare the concordance between the results of 2 types of limulus amebocyte lysate (LAL) assay, gelation (GLAL) and chromogenic (CLAL), with the detection of gram-negative bacteremia in patients with suspected bacteremia. DESIGN: Meta-analysis using receiver operating characteristic-based analytical method. DATA SOURCES: MEDLINE literature search and manual reviews of article bibliographies together with direct approaches to authors of potentially eligible studies. STUDY SELECTION: The studies that were selected had all included at least 10 patients, of whom at least 2 patients were diagnosed with gram-negative bacteremia, and all had data available for extraction into a contingency table format. RESULTS: Fifty-six studies (28 GLAL and 28 CLAL studies) met the inclusion criteria. Studies were stratified by type of test (GLAL vs CLAL). Each analysis was repeated with smaller studies excluded. There was no difference between the 2 types of LAL assays. Among the CLAL studies, there was no difference between studies that did versus those that did not use the sepsis syndrome criteria as a basis for patient inclusion. Among 45 studies for which data on the proportion of non-Enterobacteriaceae were available, there was a trend toward higher concordance as this proportion increased. CONCLUSIONS: The concordance between the LAL test and the detection of gram-negative bacteremia in patients with suspected bacteremia is no higher with the CLAL assay than with the original GLAL version. However, the concordance is higher among studies with a higher proportion of non-Enterobacteriaceae among the gram-negative bacteremia isolates.
URI: http://hdl.handle.net/11054/36
metadata.dc.relation.uri: http://www.archivesofpathology.org/doi/full/10.1043/0003-9985(2000)124%3C1157:COEGNB%3E2.0.CO;2
http://www.archivesofpathology.org/action/doSearch?searchText=Concordance+of+endotoxemia+with+gram-negative+bacteremia%3A+a+meta-analysis+using+receiver+operating+characteristic+curves
ISSN: 0003-9985
Internal ID Number: 00023
Health Subject: META ANALYSIS
ENDOTOXEMIA - BLOOD
ENDOTOXEMIA - DIAGNOSIS
ENDOTOXEMIA - ETIOLOGY
ENTEROBACTERIACEAE - ISOLATION AND PURIFICATION
ENTEROBACTERIACEAE INFECTIONS - BLOOD
ENTEROBACTERIACEAE INFECTIONS - COMPLICATIONS
ENTEROBACTERIACEAE INFECTIONS - DIAGNOSIS
ENTEROBACTERIACEAE INFECTIONS - MICROBIOLOGY
EVALUATION STUDIES AS TOPIC
GRAM NEGATIVE BACTERIAL INFECTIONS - BLOOD
GRAM NEGATIVE BACTERIAL INFECTIONS - COMPLICATIONS
GRAM NEGATIVE BACTERIAL INFECTIONS - DIAGNOSIS
GRAM NEGATIVE BACTERIAL INFECTIONS - MICROBIOLOGY
HUMANS
LIMULUS TEST
LOGISTIC MODELS
PREDICTIVE VALUE OF TESTS
ROC CURVE
REPRODUCIBILITY OF RESULTS
Type: Journal Article
Article
Appears in Collections:Research Output

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