Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/35
Title: Endotoxemia and gram-negative bacteremia as predictors of outcome in sepsis: a meta-analysis using ROC curves.
Authors: Hurley, James C.
Issue Date: 2003
Publisher: Churchill Livingstone
Place of publication: Edinburgh
Journal title: Journal of Endotoxin Research
Innate Immunity
Volume: 9
Issue: 5
Start Page: 271
End Page: 279
Abstract: The prognostic value of the detection of endotoxin in plasma of patients with suspected Gram-negative sepsis is unclear despite numerous studies. Sixteen studies have reported endotoxemia detection and blood culture results with outcome data for 1937 patients with suspected Gram-negative sepsis. Comparisons of the fatality rates for the subgroups of patients with, respectively, either endotoxemia (group 3), or Gram-negative bacteremia (group 2), or both detected (group 1), versus the fatality rate for the subgroup of patients with these factors absent (group 4), were made based on summary odds ratios (and 95% CI). Summary odds ratios for the comparison of group 2 versus group 4 and group 3 versus group 4 were non-significant (2.2; 0.9-5.8 and 2.0; 0.8-4.8, respectively). The summary odds ratio was significant for group 1 versus group 4 (3.6; 2.1-6.3), and more so among studies in which non-Enterobacteriaceae were common among the Gram-negative blood culture isolates (4.8; 2.1-10.7). Endotoxemia, like Gram-negative bacteremia, is a weak prognostic indicator. Endotoxemia appears to have most prognostic significance when it is detected in the co-presence of Gram-negative bacteremia. The differing interpretations among published studies could be attributed to the variability in types of Gram-negative bacteremia observed.
URI: http://hdl.handle.net/11054/35
ISSN: 0968-0519
Internal ID Number: 00022
Health Subject: META ANALYSIS
ENDOTOXEMIA - ETIOLOGY
ENDOTOXEMIA - MORTALITY
GRAM NEGATIVE BACTERIAL INFECTIONS - COMPLICATIONS
GRAM NEGATIVE BACTERIAL INFECTIONS - MORTALITY
HUMANS
ODDS RATIO
PROGNOSIS
ROC CURVE
SEPSIS - COMPLICATIONS
SEPSIS - MORTALITY
SURVIVAL RATE
Type: Journal Article
Article
Appears in Collections:Research Output

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