Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/32
Title: Paracetamol overdose and hepatotoxicity at a regional Australian hospital: a 4-year experience.
Authors: Ayonrinde, O. T.
Phelps, Grant J.
Hurley, James C.
Ayonrinde, O. A.
Issue Date: 2005
Publisher: Blackwell Science Asia
Place of publication: Carlton, Victoria
Journal title: Australian and New Zealand Journal of Medicine
Volume: 35
Issue: 11
Start Page: 655
End Page: 660
Abstract: BACKGROUND: Paracetamol is a component of a number of drugs taken in overdose (OD). The influence of alcohol use (acute or chronic) on the presentation and clinical course of paracetamol OD is contentious. This study explores the relationship between paracetamol OD, alcohol consumption and clinical outcomes at a regional Australian hospital. AIMS: To determine the frequency, circumstances and outcomes of paracetamol OD presentations to a regional Australian general hospital over a 4-year period. METHODS: Medical records of patients admitted to the Ballarat Health Services (BHS) as a result of paracetamol OD between January 2000 and December 2003 were reviewed. Patient demographics, amount of paracetamol ingested, other drug coingestions, alcohol history, previous medication OD, clinical course and outcomes were recorded. RESULTS: Annual admissions resulting from paracetamol OD almost doubled during the 4 years studied. The risk of a repeat paracetamol OD was highest within 4 weeks of the initial OD. Alcohol, benzodiazepines and antidepressants were commonly coingested. The strongest predictor of severe hepatotoxicity was delayed or no N-acetyl cysteine treatment in patients consuming greater than 10 g of paracetamol or with toxic serum paracetamol levels. A history of alcohol consumption did not appear to worsen outcomes.
URI: http://hdl.handle.net/11054/32
ISSN: 1444-0903
Internal ID Number: 00019
Health Subject: ACETAMINOPHEN POISONING
ADOLESCENT
ADULT
AGE DISTRIBUTION
AGED
AGED 80 AND OVER
ALCOHOL DRINKING - EPIDEMIOLOGY
AUSTRALIA - EPIDEMIOLOGY
CHILD
COMORBIDITY
DRUG INDUCED LIVER INJURY - EPIDEMIOLOGY
DRUG INDUCED LIVER INJURY - ETIOLOGY
FEMALE
HOSPITALIZATION STATISTICS AND NUMERICAL DATA
HUMANS
INFANT
MALE
OVERDOSE
PREVALENCE
MIDDLE AGED
RETROSPECTIVE STUDIES
RISK ASSESSMENT - METHODS
RISK FACTORS
SEX DISTRIBUTION
ACETAMINOPHEN
Type: Journal Article
Article
Appears in Collections:Research Output

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