Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/268
Title: Management of blood glucose in the critically ill in Australia and New Zealand: a practice survey and inception cohort study.
Authors: Mitchell, Imogen
Finfer, Simon
Bellomo, Rinaldo
Higlett, Tracy
Institutional Author: ANZICS Clinical Trials Group
Issue Date: 2006
Publisher: Springer Verlag
Place of publication: Germany
Journal title: Intensive Care Medicine
Volume: 32
Issue: 6
Start Page: 867
End Page: 874
Abstract: OBJECTIVE: To document current management of blood glucose in Australian and New Zealand intensive care units (ICUs) and to investigate the association between insulin administration, blood glucose concentration and hospital outcome. DESIGN AND SETTING: Practice survey and inception cohort study in closed multi-disciplinary ICUs in Australia and New Zealand. PATIENTS: Twenty-nine ICU directors and 939 consecutive admissions to 29 ICUs during a 2-week period. MEASUREMENT AND RESULTS: Data collected included unit approaches to blood glucose management, patient characteristics, blood glucose concentrations, insulin administration and patient outcomes. Ten percent of the ICU directors reported using an intensive insulin regimen in all their patients. In 861 patients (91.7%) blood glucose concentration was greater than 6.1[Symbol: see text]mmol/l, 287 (31.1%) received insulin, and the median blood glucose concentration triggering insulin administration was 11.5 (IQR 9.4-14) mmol/l. Univariate analysis demonstrated that non-survivors had a higher maximum daily blood glucose concentration (12 mmol/l, 9.4-14.8, vs. 9.5, 7.6-12.2) and were more likely to receive insulin (47% vs. 28%). Multiple logistic regression analysis showed age (OR per 5-year decrease 0.93, 95% CI 0.87-1.00) and APACHE II (OR per point decrease 0.87, 95% CI 0.84-0.90) to be independently associated with hospital mortality. After controlling for age and APACHE II both daily highest blood glucose (OR 0.95, 95% CI 0.90-1.00) and administration of insulin (OR 0.62, 95% CI 0.39-1.00) were independently associated when added to the model alone; neither was independently associated when they were simultaneously included in the model. CONCLUSION: Few Australian and New Zealand ICUs have adopted intensive insulin therapy. In this study, insulin administration and highest daily blood glucose concentration could not be separated in their association with hospital mortality. This study was undertaken with data obtained from Ballarat Health Services - T. Sutherland.
URI: http://hdl.handle.net/11054/268
metadata.dc.relation.uri: http://www.ncbi.nlm.nih.gov/pubmed/16622639
ISSN: 0342-4642
Internal ID Number: 00250
Health Subject: BLOOD GLUCOSE
DIABETES
CLINICAL TRIAL
ICU
GLYCAEMIC CONTROL
HYPERGLYCAEMIA
HYPOGLYCAEMIA
INSULIN
INTENSIVE CARE
HOSPITAL MORTALITY
Type: Journal Article
Article
Appears in Collections:Research Output

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